Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis

Background Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to as...

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Bibliographic Details
Published in:Cancer reports 2024-03, Vol.7 (3), p.e2029-n/a
Main Authors: Shobeiri, Parnian, Arabzadeh Bahri, Razman, Khadembashiri, Mohamad Mehdi, Khadembashiri, Mohamad Amin, Maleki, Saba, Eslami, Mohammad, Khalili Dehkordi, Marzie, Behnoush, Amir Hossein, Rezaei, Nima
Format: Article
Language:English
Subjects:
Accuracy
Bibliometrics
Bile Duct Neoplasms - diagnosis
Bile Duct Neoplasms - genetics
Bile Duct Neoplasms - pathology
Bile Ducts, Intrahepatic - pathology
Biomarkers
Cholangiocarcinoma
Cholangiocarcinoma - diagnosis
Cholangiocarcinoma - genetics
Cholangiocarcinoma - pathology
diagnosis
Disease
Epigenetics
Humans
long non‐coding RNA
Medical prognosis
Meta-analysis
MicroRNAs
Mortality
RNA, Long Noncoding - genetics
Sensitivity and Specificity
Survival analysis
Systematic review
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Summary:Background Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically. Methods International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/ and full‐text, necessary data were extracted. Random‐effect meta‐analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA. Results A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta‐analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p 
ISSN:2573-8348
2573-8348
DOI:10.1002/cnr2.2029