Loading…
Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis
Background Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to as...
Saved in:
| Published in: | Cancer reports 2024-03, Vol.7 (3), p.e2029-n/a |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4819-79b67f160c74f883de25a0c11c7dbdea25f07463fc26b0731701e6bf27e50b8d3 |
| container_end_page | n/a |
| container_issue | 3 |
| container_start_page | e2029 |
| container_title | Cancer reports |
| container_volume | 7 |
| creator | Shobeiri, Parnian Arabzadeh Bahri, Razman Khadembashiri, Mohamad Mehdi Khadembashiri, Mohamad Amin Maleki, Saba Eslami, Mohammad Khalili Dehkordi, Marzie Behnoush, Amir Hossein Rezaei, Nima |
| description | Background
Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically.
Methods
International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/ and full‐text, necessary data were extracted. Random‐effect meta‐analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA.
Results
A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta‐analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p |
| doi_str_mv | 10.1002/cnr2.2029 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_5f6ae33a623141f8890dfaa74eb94d63</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_5f6ae33a623141f8890dfaa74eb94d63</doaj_id><sourcerecordid>2974004014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4819-79b67f160c74f883de25a0c11c7dbdea25f07463fc26b0731701e6bf27e50b8d3</originalsourceid><addsrcrecordid>eNp1kctuEzEUhi0EolXoghdAltjAIu3xZcYedlHEpVJVpAiWyPLYx8HRzLjYCVV2PALPyJPgNKVCSKx80afPv89PyHMG5wyAX7gp83MOvHtETnmjxFwLqR__tT8hZ6VsAIDpVvBOPCUnQjdMSehOyZdVGpCmQIc0remUpl8_frrkYz2srheFxom6r2mw0zomZ7OLUxrtG7qgZV-2ONptdDTj94i31E6ejri11WAnO-xLLM_Ik2CHgmf364x8fvf20_LD_Orj-8vl4mrupGbdXHV9qwJrwSkZtBYeeWPBMeaU7z1a3gRQshXB8bYHJZgChm0fuMIGeu3FjFwevT7ZjbnJcbR5b5KN5u4i5bWxuUYd0DShtSiEbblgktXXOvDBWiWx76RvRXW9Orpucvq2w7I1YywOhzoDTLtieFcnBxKYrOjLf9BN2uX692IEdMC55jXtjLw-Ui6nUjKGh4AMzKFCc6jQHCqs7It7464f0T-QfwqrwMURuI0D7v9vMsvrFb9T_gahTKU7</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090228207</pqid></control><display><type>article</type><title>Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis</title><source>Wiley-Blackwell Open Access Collection</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Wiley-Blackwell Read & Publish Collection</source><source>PubMed Central</source><creator>Shobeiri, Parnian ; Arabzadeh Bahri, Razman ; Khadembashiri, Mohamad Mehdi ; Khadembashiri, Mohamad Amin ; Maleki, Saba ; Eslami, Mohammad ; Khalili Dehkordi, Marzie ; Behnoush, Amir Hossein ; Rezaei, Nima</creator><creatorcontrib>Shobeiri, Parnian ; Arabzadeh Bahri, Razman ; Khadembashiri, Mohamad Mehdi ; Khadembashiri, Mohamad Amin ; Maleki, Saba ; Eslami, Mohammad ; Khalili Dehkordi, Marzie ; Behnoush, Amir Hossein ; Rezaei, Nima</creatorcontrib><description>Background
Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically.
Methods
International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/ and full‐text, necessary data were extracted. Random‐effect meta‐analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA.
Results
A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta‐analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p < .01). Additionally, overall sensitivity of 0.80 (95% CI 0.75–0.84) and specificity of 0.77 (95% CI: 0.68–0.84) were observed. Measurement of lncRANs in the assessment of CCA also improved overall survival significantly (effect size 1.61, 95% CI: 1.39–1.82). A similar result was found for progression‐free survival (effect size 1.57, 95% CI: 1.20–1.93).
Conclusion
Based on our findings, lncRNAs showed promising results as biomarkers in the diagnosis of CCA since they had acceptable sensitivity and specificity, in addition to the fact that improved survival in this poor prognosis cancer. Further studies might be needed to address this issue and find the best clinically useful lncRNA.</description><identifier>ISSN: 2573-8348</identifier><identifier>EISSN: 2573-8348</identifier><identifier>DOI: 10.1002/cnr2.2029</identifier><identifier>PMID: 38517409</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Accuracy ; Bibliometrics ; Bile Duct Neoplasms - diagnosis ; Bile Duct Neoplasms - genetics ; Bile Duct Neoplasms - pathology ; Bile Ducts, Intrahepatic - pathology ; Biomarkers ; Cholangiocarcinoma ; Cholangiocarcinoma - diagnosis ; Cholangiocarcinoma - genetics ; Cholangiocarcinoma - pathology ; diagnosis ; Disease ; Epigenetics ; Humans ; long non‐coding RNA ; Medical prognosis ; Meta-analysis ; MicroRNAs ; Mortality ; RNA, Long Noncoding - genetics ; Sensitivity and Specificity ; Survival analysis ; Systematic review</subject><ispartof>Cancer reports, 2024-03, Vol.7 (3), p.e2029-n/a</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC.</rights><rights>2024 The Authors. Cancer Reports published by Wiley Periodicals LLC.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4819-79b67f160c74f883de25a0c11c7dbdea25f07463fc26b0731701e6bf27e50b8d3</cites><orcidid>0000-0002-9955-4227 ; 0000-0002-3836-1827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcnr2.2029$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3090228207?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,11541,25731,27901,27902,36989,36990,44566,46027,46451</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38517409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shobeiri, Parnian</creatorcontrib><creatorcontrib>Arabzadeh Bahri, Razman</creatorcontrib><creatorcontrib>Khadembashiri, Mohamad Mehdi</creatorcontrib><creatorcontrib>Khadembashiri, Mohamad Amin</creatorcontrib><creatorcontrib>Maleki, Saba</creatorcontrib><creatorcontrib>Eslami, Mohammad</creatorcontrib><creatorcontrib>Khalili Dehkordi, Marzie</creatorcontrib><creatorcontrib>Behnoush, Amir Hossein</creatorcontrib><creatorcontrib>Rezaei, Nima</creatorcontrib><title>Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis</title><title>Cancer reports</title><addtitle>Cancer Rep (Hoboken)</addtitle><description>Background
Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically.
Methods
International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/ and full‐text, necessary data were extracted. Random‐effect meta‐analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA.
Results
A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta‐analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p < .01). Additionally, overall sensitivity of 0.80 (95% CI 0.75–0.84) and specificity of 0.77 (95% CI: 0.68–0.84) were observed. Measurement of lncRANs in the assessment of CCA also improved overall survival significantly (effect size 1.61, 95% CI: 1.39–1.82). A similar result was found for progression‐free survival (effect size 1.57, 95% CI: 1.20–1.93).
Conclusion
Based on our findings, lncRNAs showed promising results as biomarkers in the diagnosis of CCA since they had acceptable sensitivity and specificity, in addition to the fact that improved survival in this poor prognosis cancer. Further studies might be needed to address this issue and find the best clinically useful lncRNA.</description><subject>Accuracy</subject><subject>Bibliometrics</subject><subject>Bile Duct Neoplasms - diagnosis</subject><subject>Bile Duct Neoplasms - genetics</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Ducts, Intrahepatic - pathology</subject><subject>Biomarkers</subject><subject>Cholangiocarcinoma</subject><subject>Cholangiocarcinoma - diagnosis</subject><subject>Cholangiocarcinoma - genetics</subject><subject>Cholangiocarcinoma - pathology</subject><subject>diagnosis</subject><subject>Disease</subject><subject>Epigenetics</subject><subject>Humans</subject><subject>long non‐coding RNA</subject><subject>Medical prognosis</subject><subject>Meta-analysis</subject><subject>MicroRNAs</subject><subject>Mortality</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Sensitivity and Specificity</subject><subject>Survival analysis</subject><subject>Systematic review</subject><issn>2573-8348</issn><issn>2573-8348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kctuEzEUhi0EolXoghdAltjAIu3xZcYedlHEpVJVpAiWyPLYx8HRzLjYCVV2PALPyJPgNKVCSKx80afPv89PyHMG5wyAX7gp83MOvHtETnmjxFwLqR__tT8hZ6VsAIDpVvBOPCUnQjdMSehOyZdVGpCmQIc0remUpl8_frrkYz2srheFxom6r2mw0zomZ7OLUxrtG7qgZV-2ONptdDTj94i31E6ejri11WAnO-xLLM_Ik2CHgmf364x8fvf20_LD_Orj-8vl4mrupGbdXHV9qwJrwSkZtBYeeWPBMeaU7z1a3gRQshXB8bYHJZgChm0fuMIGeu3FjFwevT7ZjbnJcbR5b5KN5u4i5bWxuUYd0DShtSiEbblgktXXOvDBWiWx76RvRXW9Orpucvq2w7I1YywOhzoDTLtieFcnBxKYrOjLf9BN2uX692IEdMC55jXtjLw-Ui6nUjKGh4AMzKFCc6jQHCqs7It7464f0T-QfwqrwMURuI0D7v9vMsvrFb9T_gahTKU7</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Shobeiri, Parnian</creator><creator>Arabzadeh Bahri, Razman</creator><creator>Khadembashiri, Mohamad Mehdi</creator><creator>Khadembashiri, Mohamad Amin</creator><creator>Maleki, Saba</creator><creator>Eslami, Mohammad</creator><creator>Khalili Dehkordi, Marzie</creator><creator>Behnoush, Amir Hossein</creator><creator>Rezaei, Nima</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9955-4227</orcidid><orcidid>https://orcid.org/0000-0002-3836-1827</orcidid></search><sort><creationdate>202403</creationdate><title>Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis</title><author>Shobeiri, Parnian ; Arabzadeh Bahri, Razman ; Khadembashiri, Mohamad Mehdi ; Khadembashiri, Mohamad Amin ; Maleki, Saba ; Eslami, Mohammad ; Khalili Dehkordi, Marzie ; Behnoush, Amir Hossein ; Rezaei, Nima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4819-79b67f160c74f883de25a0c11c7dbdea25f07463fc26b0731701e6bf27e50b8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Accuracy</topic><topic>Bibliometrics</topic><topic>Bile Duct Neoplasms - diagnosis</topic><topic>Bile Duct Neoplasms - genetics</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Ducts, Intrahepatic - pathology</topic><topic>Biomarkers</topic><topic>Cholangiocarcinoma</topic><topic>Cholangiocarcinoma - diagnosis</topic><topic>Cholangiocarcinoma - genetics</topic><topic>Cholangiocarcinoma - pathology</topic><topic>diagnosis</topic><topic>Disease</topic><topic>Epigenetics</topic><topic>Humans</topic><topic>long non‐coding RNA</topic><topic>Medical prognosis</topic><topic>Meta-analysis</topic><topic>MicroRNAs</topic><topic>Mortality</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Sensitivity and Specificity</topic><topic>Survival analysis</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shobeiri, Parnian</creatorcontrib><creatorcontrib>Arabzadeh Bahri, Razman</creatorcontrib><creatorcontrib>Khadembashiri, Mohamad Mehdi</creatorcontrib><creatorcontrib>Khadembashiri, Mohamad Amin</creatorcontrib><creatorcontrib>Maleki, Saba</creatorcontrib><creatorcontrib>Eslami, Mohammad</creatorcontrib><creatorcontrib>Khalili Dehkordi, Marzie</creatorcontrib><creatorcontrib>Behnoush, Amir Hossein</creatorcontrib><creatorcontrib>Rezaei, Nima</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cancer reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shobeiri, Parnian</au><au>Arabzadeh Bahri, Razman</au><au>Khadembashiri, Mohamad Mehdi</au><au>Khadembashiri, Mohamad Amin</au><au>Maleki, Saba</au><au>Eslami, Mohammad</au><au>Khalili Dehkordi, Marzie</au><au>Behnoush, Amir Hossein</au><au>Rezaei, Nima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis</atitle><jtitle>Cancer reports</jtitle><addtitle>Cancer Rep (Hoboken)</addtitle><date>2024-03</date><risdate>2024</risdate><volume>7</volume><issue>3</issue><spage>e2029</spage><epage>n/a</epage><pages>e2029-n/a</pages><issn>2573-8348</issn><eissn>2573-8348</eissn><abstract>Background
Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically.
Methods
International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/ and full‐text, necessary data were extracted. Random‐effect meta‐analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA.
Results
A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta‐analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p < .01). Additionally, overall sensitivity of 0.80 (95% CI 0.75–0.84) and specificity of 0.77 (95% CI: 0.68–0.84) were observed. Measurement of lncRANs in the assessment of CCA also improved overall survival significantly (effect size 1.61, 95% CI: 1.39–1.82). A similar result was found for progression‐free survival (effect size 1.57, 95% CI: 1.20–1.93).
Conclusion
Based on our findings, lncRNAs showed promising results as biomarkers in the diagnosis of CCA since they had acceptable sensitivity and specificity, in addition to the fact that improved survival in this poor prognosis cancer. Further studies might be needed to address this issue and find the best clinically useful lncRNA.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>38517409</pmid><doi>10.1002/cnr2.2029</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-9955-4227</orcidid><orcidid>https://orcid.org/0000-0002-3836-1827</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2573-8348 |
| ispartof | Cancer reports, 2024-03, Vol.7 (3), p.e2029-n/a |
| issn | 2573-8348 2573-8348 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_5f6ae33a623141f8890dfaa74eb94d63 |
| source | Wiley-Blackwell Open Access Collection; Publicly Available Content Database (Proquest) (PQ_SDU_P3); Wiley-Blackwell Read & Publish Collection; PubMed Central |
| subjects | Accuracy Bibliometrics Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - genetics Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Biomarkers Cholangiocarcinoma Cholangiocarcinoma - diagnosis Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology diagnosis Disease Epigenetics Humans long non‐coding RNA Medical prognosis Meta-analysis MicroRNAs Mortality RNA, Long Noncoding - genetics Sensitivity and Specificity Survival analysis Systematic review |
| title | Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T13%3A45%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20long%20non%E2%80%90coding%20RNAs%20in%20cholangiocarcinoma:%20A%20systematic%20review%20and%20meta%E2%80%90analysis&rft.jtitle=Cancer%20reports&rft.au=Shobeiri,%20Parnian&rft.date=2024-03&rft.volume=7&rft.issue=3&rft.spage=e2029&rft.epage=n/a&rft.pages=e2029-n/a&rft.issn=2573-8348&rft.eissn=2573-8348&rft_id=info:doi/10.1002/cnr2.2029&rft_dat=%3Cproquest_doaj_%3E2974004014%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4819-79b67f160c74f883de25a0c11c7dbdea25f07463fc26b0731701e6bf27e50b8d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3090228207&rft_id=info:pmid/38517409&rfr_iscdi=true |