Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses

Interferon (IFN) treatment induces the expression of hundreds of IFN-stimulated genes (ISGs). However, only a selection of their products have been demonstrated to be responsible for the inhibition of rhabdovirus replication in cultured cells; and only a few have been shown to play a role in mediati...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2015-07, Vol.7 (7), p.3675-3702
Main Authors: Blondel, Danielle, Maarifi, Ghizlane, Nisole, Sébastien, Chelbi-Alix, Mounira K
Format: Article
Language:English
Subjects:
Animals
Humans
interferon
Interferons - genetics
Interferons - immunology
ISG
Life Sciences
rabies virus
Review
Rhabdoviridae - genetics
Rhabdoviridae - physiology
Rhabdoviridae Infections - genetics
Rhabdoviridae Infections - immunology
Rhabdoviridae Infections - virology
rhabdoviruses
vesicular stomatitis virus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Interferon (IFN) treatment induces the expression of hundreds of IFN-stimulated genes (ISGs). However, only a selection of their products have been demonstrated to be responsible for the inhibition of rhabdovirus replication in cultured cells; and only a few have been shown to play a role in mediating the antiviral response in vivo using gene knockout mouse models. IFNs inhibit rhabdovirus replication at different stages via the induction of a variety of ISGs. This review will discuss how individual ISG products confer resistance to rhabdoviruses by blocking viral entry, degrading single stranded viral RNA, inhibiting viral translation or preventing release of virions from the cell. Furthermore, this review will highlight how these viruses counteract the host IFN system.
ISSN:1999-4915
1999-4915
DOI:10.3390/v7072794