In Silico Evaluation of Lawsonia intracellularis Genes Orthologous to Genes Associated with Pathogenesis in Other Intracellular Bacteria

Proliferative enteropathy is an enteric disease caused by the bacterium , which affects several species of domestic and wild animals. The mechanisms underlying the mechanisms employed by to cause host cell proliferation are poorly understood, mostly because this bacterium is extremely difficult to i...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-08, Vol.12 (8), p.1596
Main Authors: Suarez-Duarte, Mirtha E, Santos, Renato L, Pereira, Carlos E R, Resende, Talita P, Araujo, Matheus D, Correia, Paula A, Barbosa, Jessica C R, Laub, Ricardo P, Rodrigues, Diego L N, Aburjaile, Flavia F, Guedes, Roberto M C
Format: Article
Language:English
Subjects:
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Bacteria
Cell proliferation
Chemotaxis
DNA repair
Domestic animals
Gene expression
Genes
Genetic aspects
genome
Genomes
Homology
Hyperplasia
In vitro methods and tests
Intracellular
Invasive species
Lawsonia intracellularis
Listeria
Macrophages
Molecular modelling
Paratuberculosis
Pathogenesis
Pathogenicity
Pathogens
Phylogenetics
Plasmids
proliferative enteropathy
Proteins
Proteomes
Pseudotuberculosis
Ribosomal DNA
Survival
Tuberculosis
Virulence
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Summary:Proliferative enteropathy is an enteric disease caused by the bacterium , which affects several species of domestic and wild animals. The mechanisms underlying the mechanisms employed by to cause host cell proliferation are poorly understood, mostly because this bacterium is extremely difficult to isolate and propagate in vitro. Comparative genomics methods for searching for genes orthologous to genes known to be associated with pathogenesis allow identification of genes potentially involved in pathogenesis by the pathogen of interest. The goal of this study was to carry out in silico research on genes orthologous to genes required for intracellular invasion and survival present in other pathogenic bacteria, particularly , , , , , subspecies , , , , and . A total of 127 genes associated with invasion and intracellular survival from five known intracellular bacteria were mapped against the predicted proteomes of all strains publicly available on GenBank, using the OrthoFinder program. A total of 45 genes were orthologous to genes associated with pathogenesis of other intracellular bacteria. Genes putatively associated with signal the transduction of chemotaxis and cell motility were identified. Genes related to DNA binding and repair were also identified, with some of them supporting a possible association of bacteria with macrophages or inducing pro-inflammatory responses. The homology-based identification of these genes suggests their potential involvement in the virulence and pathogenicity of , opening avenues for future research and insights into the molecular mechanisms of -elicited proliferative enteropathy.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12081596