Computational approaches for drug repurposing in oncology: untapped opportunity for high value innovation

Historically, the effort by academia and industry to develop new chemical entities into lifesaving drugs has limited success in meeting the demands of today's healthcare. Repurposing drugs that are originally approved by the United States Food and Drug Administration or by regulatory authoritie...

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Bibliographic Details
Published in:Frontiers in oncology 2023-05, Vol.13, p.1198284-1198284
Main Authors: Dalwadi, Shraddha M, Hunt, Andrew, Bonnen, Mark D, Ghebre, Yohannes T
Format: Article
Language:English
Subjects:
clinical trials
drug repurposing
informatics
Oncology
pharmacology
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Summary:Historically, the effort by academia and industry to develop new chemical entities into lifesaving drugs has limited success in meeting the demands of today's healthcare. Repurposing drugs that are originally approved by the United States Food and Drug Administration or by regulatory authorities around the globe is an attractive strategy to rapidly develop much-needed therapeutics for oncologic indications that extend from treating cancer to managing treatment-related complications. This review discusses computational approaches to harness existing drugs for new therapeutic use in oncology.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1198284