Role of [ 18 F]FDG PET/CT in the management of follicular cell-derived thyroid carcinoma

Follicular cell-derived thyroid carcinomas constitute the majority of thyroid malignancies. This heterogeneous group of tumours includes well differentiated, poorly differentiated, and undifferentiated forms, which have distinct pathological features, clinical behaviour, and prognosis. Positron emis...

Full description

Saved in:
Bibliographic Details
Published in:Cancer imaging 2024-10, Vol.24 (1), p.147-13, Article 147
Main Authors: Zajkowska, Klaudia, Cegla, Paulina, Dedecjus, Marek
Format: Article
Language:English
Subjects:
[18F]FDG
Adenocarcinoma, Follicular - diagnostic imaging
Adenocarcinoma, Follicular - pathology
Adenocarcinoma, Follicular - therapy
CT imaging
Dedifferentiation
Diagnosis
Fluorodeoxyglucose F18
Humans
PET imaging
PET/CT
Positron Emission Tomography Computed Tomography - methods
Prognosis
Radiopharmaceuticals
Review
TENIS syndrome
Thyroid cancer
Thyroid gland
Thyroid incidentaloma
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Thyroid Neoplasms - therapy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Follicular cell-derived thyroid carcinomas constitute the majority of thyroid malignancies. This heterogeneous group of tumours includes well differentiated, poorly differentiated, and undifferentiated forms, which have distinct pathological features, clinical behaviour, and prognosis. Positron emission tomography with 2-[ F]fluoro-2-deoxy-D-glucose combined with computed tomography ([ F]FDG PET/CT) is an imaging modality used in routine clinical practice for oncological patients. [ F]FDG PET/CT has emerged as a valuable tool for identifying patients at high risk of poor clinical outcomes and for facilitating individualized clinical decision-making. The aim of this comprehensive review is to summarize current knowledge regarding the role of [ F]FDG PET/CT in primary diagnosis, treatment, and follow-up of follicular cell-derived thyroid carcinomas considering the degree of differentiation. Controversial issues, including significance of accidentally detected [ F]FDG uptake in the thyroid, the role of [ F]FDG PET/CT in the early assessment of response to molecular targeted therapies, and its prognostic value are discussed in detail.
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-024-00791-8