Acetylharpagide Protects Mice from Staphylococcus Aureus -Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway

( )-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic ef...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-11, Vol.25 (23), p.5523
Main Authors: Zhang, Zhaoxin, Wang, Yun, Shan, Yating, Yin, Wu
Format: Article
Language:English
Subjects:
acetylharpagide
acute lung injury
Acute Lung Injury - drug therapy
Acute Lung Injury - etiology
Acute Lung Injury - metabolism
Acute Lung Injury - pathology
Animals
Biopsy
Blood-Air Barrier - drug effects
Blood-Air Barrier - metabolism
Blood-Air Barrier - pathology
Cytokines - metabolism
Histocytochemistry
Inflammation Mediators - metabolism
Lamiaceae - chemistry
Mice
Molecular Structure
NF-kappa B - metabolism
NF-κB signaling
Plant Extracts - chemistry
Plant Extracts - pharmacology
RAW 264.7 Cells
Signal Transduction - drug effects
Staphylococcal Infections - complications
Staphylococcus aureus
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Summary:( )-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic effects of acetylharpagide on -induced ALI in mice. Here, we found that acetylharpagide alleviated -induced lung pathological morphology damage, protected the pulmonary blood-gas barrier and improved the survival of -infected mice. Furthermore, -induced myeloperoxidase (MPO) activity of lung homogenate and pro-inflammatory factors in bronchoalveolar lavage (BAL) fluid were suppressed by acetylharpagide. Mechanically, acetylharpagide inhibited the interaction between polyubiquitinated receptor interacting protein 1 (RIP1) and NF-κB essential modulator (NEMO), thereby suppressing NF-κB activity. In summary, these results show that acetylharpagide protects mice from -induced ALI by suppressing the NF-κB signaling pathway. Acetylharpagide is expected to become a potential treatment for -induced ALI.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25235523