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Acetylharpagide Protects Mice from Staphylococcus Aureus -Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway
( )-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic ef...
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Published in: | Molecules (Basel, Switzerland) Switzerland), 2020-11, Vol.25 (23), p.5523 |
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container_title | Molecules (Basel, Switzerland) |
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creator | Zhang, Zhaoxin Wang, Yun Shan, Yating Yin, Wu |
description | (
)-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of
Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic effects of acetylharpagide on
-induced ALI in mice. Here, we found that acetylharpagide alleviated
-induced lung pathological morphology damage, protected the pulmonary blood-gas barrier and improved the survival of
-infected mice. Furthermore,
-induced myeloperoxidase (MPO) activity of lung homogenate and pro-inflammatory factors in bronchoalveolar lavage (BAL) fluid were suppressed by acetylharpagide. Mechanically, acetylharpagide inhibited the interaction between polyubiquitinated receptor interacting protein 1 (RIP1) and NF-κB essential modulator (NEMO), thereby suppressing NF-κB activity. In summary, these results show that acetylharpagide protects mice from
-induced ALI by suppressing the NF-κB signaling pathway. Acetylharpagide is expected to become a potential treatment for
-induced ALI. |
doi_str_mv | 10.3390/molecules25235523 |
format | article |
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)-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of
Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic effects of acetylharpagide on
-induced ALI in mice. Here, we found that acetylharpagide alleviated
-induced lung pathological morphology damage, protected the pulmonary blood-gas barrier and improved the survival of
-infected mice. Furthermore,
-induced myeloperoxidase (MPO) activity of lung homogenate and pro-inflammatory factors in bronchoalveolar lavage (BAL) fluid were suppressed by acetylharpagide. Mechanically, acetylharpagide inhibited the interaction between polyubiquitinated receptor interacting protein 1 (RIP1) and NF-κB essential modulator (NEMO), thereby suppressing NF-κB activity. In summary, these results show that acetylharpagide protects mice from
-induced ALI by suppressing the NF-κB signaling pathway. Acetylharpagide is expected to become a potential treatment for
-induced ALI.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules25235523</identifier><identifier>PMID: 33255656</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>acetylharpagide ; acute lung injury ; Acute Lung Injury - drug therapy ; Acute Lung Injury - etiology ; Acute Lung Injury - metabolism ; Acute Lung Injury - pathology ; Animals ; Biopsy ; Blood-Air Barrier - drug effects ; Blood-Air Barrier - metabolism ; Blood-Air Barrier - pathology ; Cytokines - metabolism ; Histocytochemistry ; Inflammation Mediators - metabolism ; Lamiaceae - chemistry ; Mice ; Molecular Structure ; NF-kappa B - metabolism ; NF-κB signaling ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; RAW 264.7 Cells ; Signal Transduction - drug effects ; Staphylococcal Infections - complications ; Staphylococcus aureus</subject><ispartof>Molecules (Basel, Switzerland), 2020-11, Vol.25 (23), p.5523</ispartof><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c3dab6ba633fcd3673464843c6cd9f0b270e33344b792e86a8c60d95fe19e6e83</citedby><cites>FETCH-LOGICAL-c465t-c3dab6ba633fcd3673464843c6cd9f0b270e33344b792e86a8c60d95fe19e6e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728067/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728067/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33255656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhaoxin</creatorcontrib><creatorcontrib>Wang, Yun</creatorcontrib><creatorcontrib>Shan, Yating</creatorcontrib><creatorcontrib>Yin, Wu</creatorcontrib><title>Acetylharpagide Protects Mice from Staphylococcus Aureus -Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>(
)-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of
Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic effects of acetylharpagide on
-induced ALI in mice. Here, we found that acetylharpagide alleviated
-induced lung pathological morphology damage, protected the pulmonary blood-gas barrier and improved the survival of
-infected mice. Furthermore,
-induced myeloperoxidase (MPO) activity of lung homogenate and pro-inflammatory factors in bronchoalveolar lavage (BAL) fluid were suppressed by acetylharpagide. Mechanically, acetylharpagide inhibited the interaction between polyubiquitinated receptor interacting protein 1 (RIP1) and NF-κB essential modulator (NEMO), thereby suppressing NF-κB activity. In summary, these results show that acetylharpagide protects mice from
-induced ALI by suppressing the NF-κB signaling pathway. Acetylharpagide is expected to become a potential treatment for
-induced ALI.</description><subject>acetylharpagide</subject><subject>acute lung injury</subject><subject>Acute Lung Injury - drug therapy</subject><subject>Acute Lung Injury - etiology</subject><subject>Acute Lung Injury - metabolism</subject><subject>Acute Lung Injury - pathology</subject><subject>Animals</subject><subject>Biopsy</subject><subject>Blood-Air Barrier - drug effects</subject><subject>Blood-Air Barrier - metabolism</subject><subject>Blood-Air Barrier - pathology</subject><subject>Cytokines - metabolism</subject><subject>Histocytochemistry</subject><subject>Inflammation Mediators - metabolism</subject><subject>Lamiaceae - chemistry</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB signaling</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>RAW 264.7 Cells</subject><subject>Signal Transduction - drug effects</subject><subject>Staphylococcal Infections - complications</subject><subject>Staphylococcus aureus</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNplkc9u1DAQxi0EomXhAbggH7kEnIzjxBekpaJlpQUqFc6W40wSr7Lx4j-g8Gh9CJ6JlC1VKw6jGX0z85uRPkJe5uwNgGRv925Ek0YMRVlAucQjcprzgmXAuHx8rz4hz0LYMVbkPC-fkhOAoixFKU7Jr7XBOI-D9gfd2xbppXcRTQz0kzVIO-_29CrqwzCPzjhjUqDr5HFJ2WZqk8GWrk2KSLdp6ulm2iU_02ZeqsE2NtpF_Hye_b5-T69sP-nxRrjUcfip5-fkSafHgC9u84p8O__w9exjtv1ysTlbbzPDRRkzA61uRKMFQGdaEBVwwWsORphWdqwpKoYAwHlTyQJroWsjWCvLDnOJAmtYkc2R2zq9Uwdv99rPymmr_grO90r7aM2IquykwC5HDpJzLYWsm6KRjGsUkEMtFta7I-uQmj22Bqfo9fgA-rAz2UH17oeqqqJmy-8r8voW4N33hCGqvQ0Gx1FP6FJQBReCgYC6XEbz46jxLgSP3d2ZnKkb_9V__i87r-7_d7fxz3D4A8_dsH8</recordid><startdate>20201125</startdate><enddate>20201125</enddate><creator>Zhang, Zhaoxin</creator><creator>Wang, Yun</creator><creator>Shan, Yating</creator><creator>Yin, Wu</creator><general>MDPI</general><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20201125</creationdate><title>Acetylharpagide Protects Mice from Staphylococcus Aureus -Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway</title><author>Zhang, Zhaoxin ; Wang, Yun ; Shan, Yating ; Yin, Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-c3dab6ba633fcd3673464843c6cd9f0b270e33344b792e86a8c60d95fe19e6e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>acetylharpagide</topic><topic>acute lung injury</topic><topic>Acute Lung Injury - drug therapy</topic><topic>Acute Lung Injury - etiology</topic><topic>Acute Lung Injury - metabolism</topic><topic>Acute Lung Injury - pathology</topic><topic>Animals</topic><topic>Biopsy</topic><topic>Blood-Air Barrier - drug effects</topic><topic>Blood-Air Barrier - metabolism</topic><topic>Blood-Air Barrier - pathology</topic><topic>Cytokines - metabolism</topic><topic>Histocytochemistry</topic><topic>Inflammation Mediators - metabolism</topic><topic>Lamiaceae - chemistry</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB signaling</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>RAW 264.7 Cells</topic><topic>Signal Transduction - drug effects</topic><topic>Staphylococcal Infections - complications</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zhaoxin</creatorcontrib><creatorcontrib>Wang, Yun</creatorcontrib><creatorcontrib>Shan, Yating</creatorcontrib><creatorcontrib>Yin, Wu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhaoxin</au><au>Wang, Yun</au><au>Shan, Yating</au><au>Yin, Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetylharpagide Protects Mice from Staphylococcus Aureus -Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2020-11-25</date><risdate>2020</risdate><volume>25</volume><issue>23</issue><spage>5523</spage><pages>5523-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>(
)-induced acute lung injury (ALI) is a serious disease that has a high risk of death among infants and teenagers. Acetylharpagide, a natural compound of
Thunb. (family Labiatae), has been found to have anti-tumor, anti-inflammatory and anti-viral effects. This study investigates the therapeutic effects of acetylharpagide on
-induced ALI in mice. Here, we found that acetylharpagide alleviated
-induced lung pathological morphology damage, protected the pulmonary blood-gas barrier and improved the survival of
-infected mice. Furthermore,
-induced myeloperoxidase (MPO) activity of lung homogenate and pro-inflammatory factors in bronchoalveolar lavage (BAL) fluid were suppressed by acetylharpagide. Mechanically, acetylharpagide inhibited the interaction between polyubiquitinated receptor interacting protein 1 (RIP1) and NF-κB essential modulator (NEMO), thereby suppressing NF-κB activity. In summary, these results show that acetylharpagide protects mice from
-induced ALI by suppressing the NF-κB signaling pathway. Acetylharpagide is expected to become a potential treatment for
-induced ALI.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>33255656</pmid><doi>10.3390/molecules25235523</doi><oa>free_for_read</oa></addata></record> |
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subjects | acetylharpagide acute lung injury Acute Lung Injury - drug therapy Acute Lung Injury - etiology Acute Lung Injury - metabolism Acute Lung Injury - pathology Animals Biopsy Blood-Air Barrier - drug effects Blood-Air Barrier - metabolism Blood-Air Barrier - pathology Cytokines - metabolism Histocytochemistry Inflammation Mediators - metabolism Lamiaceae - chemistry Mice Molecular Structure NF-kappa B - metabolism NF-κB signaling Plant Extracts - chemistry Plant Extracts - pharmacology RAW 264.7 Cells Signal Transduction - drug effects Staphylococcal Infections - complications Staphylococcus aureus |
title | Acetylharpagide Protects Mice from Staphylococcus Aureus -Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway |
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