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Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery
Formic acid (FA) has emerged as a promising one-carbon feedstock for biorefinery. However, developing efficient microbial hosts for economically competitive FA utilization remains a grand challenge. Here, we discover that the bacterium Vibrio natriegens has exceptional FA tolerance and metabolic cap...
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| Published in: | Nature communications 2023-11, Vol.14 (1), p.7758-7758, Article 7758 |
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| creator | Tian, Jinzhong Deng, Wangshuying Zhang, Ziwen Xu, Jiaqi Yang, Guiling Zhao, Guoping Yang, Sheng Jiang, Weihong Gu, Yang |
| description | Formic acid (FA) has emerged as a promising one-carbon feedstock for biorefinery. However, developing efficient microbial hosts for economically competitive FA utilization remains a grand challenge. Here, we discover that the bacterium
Vibrio natriegens
has exceptional FA tolerance and metabolic capacity natively. This bacterium is remodeled by rewiring the serine cycle and the TCA cycle, resulting in a non-native closed loop (S-TCA) which as a powerful metabolic sink, in combination with laboratory evolution, enables rapid emergence of synthetic strains with significantly improved FA-utilizing ability. Further introduction of a foreign indigoidine-forming pathway into the synthetic
V. natriegens
strain leads to the production of 29.0 g · L
−1
indigoidine and consumption of 165.3 g · L
−1
formate within 72 h, achieving a formate consumption rate of 2.3 g · L
−1
· h
−1
. This work provides an important microbial chassis as well as design rules to develop industrially viable microorganisms for FA biorefinery.
Formic acid (FA) is a promising CO2-equivalent feedstock for onecarbon biorefinery, but microbial host that can efficiently utilize FA is unavailable. Here, the authors engineer a non-native closed loop in
Vibrio natriegens
and demonstrate its application in promoting FA utilization. |
| doi_str_mv | 10.1038/s41467-023-43631-2 |
| format | article |
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Vibrio natriegens
has exceptional FA tolerance and metabolic capacity natively. This bacterium is remodeled by rewiring the serine cycle and the TCA cycle, resulting in a non-native closed loop (S-TCA) which as a powerful metabolic sink, in combination with laboratory evolution, enables rapid emergence of synthetic strains with significantly improved FA-utilizing ability. Further introduction of a foreign indigoidine-forming pathway into the synthetic
V. natriegens
strain leads to the production of 29.0 g · L
−1
indigoidine and consumption of 165.3 g · L
−1
formate within 72 h, achieving a formate consumption rate of 2.3 g · L
−1
· h
−1
. This work provides an important microbial chassis as well as design rules to develop industrially viable microorganisms for FA biorefinery.
Formic acid (FA) is a promising CO2-equivalent feedstock for onecarbon biorefinery, but microbial host that can efficiently utilize FA is unavailable. Here, the authors engineer a non-native closed loop in
Vibrio natriegens
and demonstrate its application in promoting FA utilization.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/s41467-023-43631-2</identifier><identifier>PMID: 38012202</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 45/22 ; 45/23 ; 45/70 ; 45/90 ; 45/91 ; 631/1647/2234 ; 631/326/2522 ; 631/61/318 ; 631/92/552 ; Bacteria ; Biorefineries ; Carbon dioxide ; Closed loops ; Consumption ; Formic acid ; Humanities and Social Sciences ; Metabolism ; Microorganisms ; multidisciplinary ; Raw materials ; Refining ; Science ; Science (multidisciplinary) ; Tricarboxylic acid cycle ; Vibrio natriegens</subject><ispartof>Nature communications, 2023-11, Vol.14 (1), p.7758-7758, Article 7758</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-8d286e0b2f6da317233dcf9311562c13ce242494bdc47cc1718d7cc26ca10433</citedby><cites>FETCH-LOGICAL-c518t-8d286e0b2f6da317233dcf9311562c13ce242494bdc47cc1718d7cc26ca10433</cites><orcidid>0000-0001-7637-084X ; 0000-0003-3742-9989 ; 0000-0002-2866-5675 ; 0000-0003-2291-8579</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2894164163/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2894164163?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids></links><search><creatorcontrib>Tian, Jinzhong</creatorcontrib><creatorcontrib>Deng, Wangshuying</creatorcontrib><creatorcontrib>Zhang, Ziwen</creatorcontrib><creatorcontrib>Xu, Jiaqi</creatorcontrib><creatorcontrib>Yang, Guiling</creatorcontrib><creatorcontrib>Zhao, Guoping</creatorcontrib><creatorcontrib>Yang, Sheng</creatorcontrib><creatorcontrib>Jiang, Weihong</creatorcontrib><creatorcontrib>Gu, Yang</creatorcontrib><title>Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><description>Formic acid (FA) has emerged as a promising one-carbon feedstock for biorefinery. However, developing efficient microbial hosts for economically competitive FA utilization remains a grand challenge. Here, we discover that the bacterium
Vibrio natriegens
has exceptional FA tolerance and metabolic capacity natively. This bacterium is remodeled by rewiring the serine cycle and the TCA cycle, resulting in a non-native closed loop (S-TCA) which as a powerful metabolic sink, in combination with laboratory evolution, enables rapid emergence of synthetic strains with significantly improved FA-utilizing ability. Further introduction of a foreign indigoidine-forming pathway into the synthetic
V. natriegens
strain leads to the production of 29.0 g · L
−1
indigoidine and consumption of 165.3 g · L
−1
formate within 72 h, achieving a formate consumption rate of 2.3 g · L
−1
· h
−1
. This work provides an important microbial chassis as well as design rules to develop industrially viable microorganisms for FA biorefinery.
Formic acid (FA) is a promising CO2-equivalent feedstock for onecarbon biorefinery, but microbial host that can efficiently utilize FA is unavailable. Here, the authors engineer a non-native closed loop in
Vibrio natriegens
and demonstrate its application in promoting FA utilization.</description><subject>38/39</subject><subject>45/22</subject><subject>45/23</subject><subject>45/70</subject><subject>45/90</subject><subject>45/91</subject><subject>631/1647/2234</subject><subject>631/326/2522</subject><subject>631/61/318</subject><subject>631/92/552</subject><subject>Bacteria</subject><subject>Biorefineries</subject><subject>Carbon dioxide</subject><subject>Closed loops</subject><subject>Consumption</subject><subject>Formic acid</subject><subject>Humanities and Social Sciences</subject><subject>Metabolism</subject><subject>Microorganisms</subject><subject>multidisciplinary</subject><subject>Raw materials</subject><subject>Refining</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tricarboxylic acid cycle</subject><subject>Vibrio 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emerged as a promising one-carbon feedstock for biorefinery. However, developing efficient microbial hosts for economically competitive FA utilization remains a grand challenge. Here, we discover that the bacterium
Vibrio natriegens
has exceptional FA tolerance and metabolic capacity natively. This bacterium is remodeled by rewiring the serine cycle and the TCA cycle, resulting in a non-native closed loop (S-TCA) which as a powerful metabolic sink, in combination with laboratory evolution, enables rapid emergence of synthetic strains with significantly improved FA-utilizing ability. Further introduction of a foreign indigoidine-forming pathway into the synthetic
V. natriegens
strain leads to the production of 29.0 g · L
−1
indigoidine and consumption of 165.3 g · L
−1
formate within 72 h, achieving a formate consumption rate of 2.3 g · L
−1
· h
−1
. This work provides an important microbial chassis as well as design rules to develop industrially viable microorganisms for FA biorefinery.
Formic acid (FA) is a promising CO2-equivalent feedstock for onecarbon biorefinery, but microbial host that can efficiently utilize FA is unavailable. Here, the authors engineer a non-native closed loop in
Vibrio natriegens
and demonstrate its application in promoting FA utilization.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38012202</pmid><doi>10.1038/s41467-023-43631-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7637-084X</orcidid><orcidid>https://orcid.org/0000-0003-3742-9989</orcidid><orcidid>https://orcid.org/0000-0002-2866-5675</orcidid><orcidid>https://orcid.org/0000-0003-2291-8579</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature communications, 2023-11, Vol.14 (1), p.7758-7758, Article 7758 |
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| source | Nature; Publicly Available Content (ProQuest); PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 38/39 45/22 45/23 45/70 45/90 45/91 631/1647/2234 631/326/2522 631/61/318 631/92/552 Bacteria Biorefineries Carbon dioxide Closed loops Consumption Formic acid Humanities and Social Sciences Metabolism Microorganisms multidisciplinary Raw materials Refining Science Science (multidisciplinary) Tricarboxylic acid cycle Vibrio natriegens |
| title | Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery |
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