Electrospinning Fabrication of Poly(vinyl alcohol)/ Coptis chinensis Extract Nanofibers for Antimicrobial Exploits

(CC) is used in conventional Chinese medicine. The main active components of CC are isoquinoline alkaloids, including berberine, coptisine, palmatine, and magnoflorine; all these are known to have several pharmacological properties. Poly(vinyl alcohol) (PVA) is a well-known synthetic biocompatible p...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2018-09, Vol.8 (9), p.734
Main Authors: Yang, Seong Baek, Kim, Eun Hee, Kim, Seung Hee, Kim, Young Hun, Oh, Weontae, Lee, Jin-Tae, Jang, Young-Ah, Sabina, Yeasmin, Ji, Byung Chul, Yeum, Jeong Hyun
Format: Article
Language:English
Subjects:
Alkaloids
antibacterial
antifungal
Antifungal activity
Antimicrobial activity
Antimicrobial agents
Aqueous solutions
Aureobasidium pullulans
Berberine
Biocompatibility
Coptis chinensis
Cosmetics
Emission analysis
Ethanol
extract
Fabrication
Food industry
Food packaging
Fourier transforms
Fungi
Fungicides
Herbal medicine
Infrared analysis
Metabolism
Molecular weight
Morphology
Nanofibers
Pharmaceuticals
Pharmacology
Poly(vinyl alcohol)
Polymer melts
Polymers
Polyvinyl alcohol
Researchers
Scanning electron microscopy
Stability analysis
Staphylococcus aureus
Staphylococcus infections
Thermal stability
Thermogravimetric analysis
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Summary:(CC) is used in conventional Chinese medicine. The main active components of CC are isoquinoline alkaloids, including berberine, coptisine, palmatine, and magnoflorine; all these are known to have several pharmacological properties. Poly(vinyl alcohol) (PVA) is a well-known synthetic biocompatible polymer suitable for a range of pharmaceutical uses; it can be used as a matrix for the incorporation of functional materials and has a wide range of applications in the cosmetics, food, pharmaceutical, and packaging industries. In this study, PVA-based electrospun nanofibers containing CC extract were successfully fabricated. Furthermore, the effects of different CC extract contents on the morphologies, and antimicrobial and antifungal properties of PVA/CC extract nanofibers were investigated. Morphological changes were observed using different molecular weights of PVA. For characterization, field-emission scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared analysis were performed. The effectiveness of these nanofibers has been demonstrated by evaluating the thermal stability against , antimicrobial activity against and , and the antifungal activity against the fungi and . The PVA/CC extract nanofibers were found to have excellent antibacterial and antifungal activity and thermal stability; hence, their use in medicinal sectors is highly recommended.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano8090734