Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-cause mortality in coronary artery disease patients with congestive heart failure

• Published in: BMC cardiovascular disorders 2021-12, Vol.21 (1), p.618-618, Article 618
• Main Authors: Bao, Kunming, Huang, Haozhang, Huang, Guoyong, Wang, Junjie, Liao, Ying, Pan, Yuxiong, Chen, Weihua, Lu, Jin, Yang, Yanfang, Huang, Zhidong, Chen, Shiqun, Chen, Kaihong, Chen, Liling
• Format: Article
• Language: English
• Subjects: Age; Aged; Angiography; Angioplasty; Biomarkers; Biomarkers - blood; Blood cell count; Blood Platelets; Cardiovascular disease; Cause of Death; Complications and side effects; Congestive heart failure; Coronary Angiography; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - mortality; Coronary heart disease; Coronary vessels; Female; Glycosylated hemoglobin; Health aspects; Heart attacks; Heart failure; Heart Failure - blood; Heart Failure - diagnosis; Heart Failure - mortality; Hemoglobin; Hemoglobins - analysis; Hospitals; Humans; Ischemia; Male; Medical imaging; Medical prognosis; Middle Aged; Mortality; Patient outcomes; Patients; Platelet Count; Platelet-to-hemoglobin ratio; Platelets; Population; Predictive Value of Tests; Prognosis; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Trinucleotide repeats; Vein & artery diseases
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-021-02423-6

The platelet-to-hemoglobin ratio (PHR) has emerged as a prognostic biomarker in coronary artery disease (CAD) patients after PCI but not clear in CAD complicated with congestive heart failure (CHF). Hence, we aimed to assess the association between PHR and long-term all-cause mortality among CAD patients with CHF. Based on the registry at Guangdong Provincial People's Hospital in China, we analyzed data of 2599 hospitalized patients who underwent coronary angiography (CAG) and were diagnosed with CAD complicated by CHF from January 2007 to December 2018. Low PHR was defined as ˂ 1.69 (group 1) and high PHR as ≥ 1.69 (group 2). Prognosis analysis was performed using Kaplan-Meier method. To assess the association between PHR and long-term all-cause mortality, a Cox-regression model was fitted. During a median follow-up of 5.2 (3.1-7.8) years, a total of 985 (37.9%) patients died. On the Kaplan-Meier analysis, patients in high PHR group had a worse prognosis than those in low PHR group (log-rank, p = 0.0011). After adjustment for confounders, high PHR was correlated with an increased risk of long-term all-cause mortality in CAD patients complicated with CHF. (adjusted hazard ratio [aHR], 1.31; 95% confidence interval [CI], 1.13-1.52, p