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Ameloblastomas: current aspects of the new WHO classification in an analysis of 136 cases

Introduction Ameloblastomas are neoplasms that have inspired great controversy and clinical interest; their incidence, radiographic features, treatment and behavior are still discussed quite often in the literature. In 2017, the classification of these lesions underwent modifications in terminology...

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Published in:Surgical and experimental pathology 2019-06, Vol.2 (1), p.1-6, Article 17
Main Authors: Cadavid, Ana Maria Hoyos, Araujo, Juliane Piragine, Coutinho-Camillo, Cláudia Malheiros, Bologna, Sheyla, Junior, Celso Augusto Lemos, Lourenço, Silvia Vanessa
Format: Article
Language:English
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Summary:Introduction Ameloblastomas are neoplasms that have inspired great controversy and clinical interest; their incidence, radiographic features, treatment and behavior are still discussed quite often in the literature. In 2017, the classification of these lesions underwent modifications in terminology with the introduction of prospective views based on updates in current genetic studies. Objective To describe the most important features of the new classification, as well as to evaluate the prevalence and the clinical and radiographic characteristics of 136 ameloblastomas. Methodology The clinical-pathological characteristics of 136 patients diagnosed with ameloblastoma in two large hospitals in São Paulo were analyzed. All the hematoxylin-eosin (HE) stained slides were reviewed using an optical microscope (Olympus Cover) and tumors were classified according to the new WHO criteria (2017). Two independent evaluators analyzed the slides; in cases where there was disagreement a third evaluator was used and the result was established in consensus. Results 71% of the lesions were of the conventional type, the predominant histopathological pattern being plexiform (40%), 72% of the tumors showed cortical expansion, and 84% had a radiographic pattern of the multilocular type. The treatment of choice in most cases was segmental resection (45%) and recurrence was present in 13% of the cases. Conclusion Studies with clinical-pathological correlations will be necessary in the near future, in order to provide new therapies that are more effective and conservative, improving the quality of life of patients effected.
ISSN:2520-8454
2520-8454
DOI:10.1186/s42047-019-0041-z