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Nectin-4 is a new histological and serological tumor associated marker for breast cancer
Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importance of large-scale molecular expression analyses to improve taxonomy of breast cancer and pro...
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Published in: | BMC cancer 2007-05, Vol.7 (1), p.73-73, Article 73 |
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creator | Fabre-Lafay, Stéphanie Monville, Florence Garrido-Urbani, Sarah Berruyer-Pouyet, Carole Ginestier, Christophe Reymond, Nicolas Finetti, Pascal Sauvan, Richard Adélaïde, José Geneix, Jeannine Lecocq, Eric Popovici, Cornel Dubreuil, Patrice Viens, Patrice Gonçalves, Anthony Charafe-Jauffret, Emmanuelle Jacquemier, Jocelyne Birnbaum, Daniel Lopez, Marc |
description | Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importance of large-scale molecular expression analyses to improve taxonomy of breast cancer and prognostic classification. Identification of new molecular markers that refine this taxonomy and improve patient management is a priority in the field of breast cancer research.Nectins are cell adhesion molecules involved in the regulation of epithelial physiology. We present here Nectin-4/PVRL4 as a new histological and serological tumor associated marker for breast carcinoma.
Expression of Nectin-4 protein was measured on a panel of 78 primary cells and cell lines from different origins and 57 breast tumors by FACS analysis and immunohistochemistry (IHC), respectively. mRNA expression was measured by quantitative PCR. Serum Nectin-4 was detected by ELISA and compared with CEA and CA15.3 markers, on panels of 45 sera from healthy donors, 53 sera from patients with non-metastatic breast carcinoma (MBC) at diagnosis, and 182 sera from patients with MBC. Distribution of histological/serological molecular markers and histoclinical parameters were compared using the standard Chi-2 test.
Nectin-4 was not detected in normal breast epithelium. By contrast, Nectin-4 was expressed in 61% of ductal breast carcinoma vs 6% in lobular type. Expression of Nectin-4 strongly correlated with the basal-like markers EGFR, P53, and P-cadherin, and negatively correlated with the luminal-like markers ER, PR and GATA3. All but one ER/PR-negative tumors expressed Nectin-4. The detection of Nectin-4 in serum improves the follow-up of patients with MBC: the association CEA/CA15.3/Nectin-4 allowed to monitor 74% of these patients compared to 67% with the association CEA/CA15.3. Serum Nectin-4 is a marker of disease progression, and levels correlate with the number of metastases (P = 0.038). Serum Nectin-4 is also a marker of therapeutic efficiency and correlates, in 90% of cases, with clinical evolution.
Nectin-4 is a new tumor-associated antigen for breast carcinoma. Nectin-4 is a new bio-marker whose use could help refine breast cancer taxonomy and improve patients' follow-up. Nectin-4 emerges as a potential target for breast cancer immunotherapy. |
doi_str_mv | 10.1186/1471-2407-7-73 |
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Expression of Nectin-4 protein was measured on a panel of 78 primary cells and cell lines from different origins and 57 breast tumors by FACS analysis and immunohistochemistry (IHC), respectively. mRNA expression was measured by quantitative PCR. Serum Nectin-4 was detected by ELISA and compared with CEA and CA15.3 markers, on panels of 45 sera from healthy donors, 53 sera from patients with non-metastatic breast carcinoma (MBC) at diagnosis, and 182 sera from patients with MBC. Distribution of histological/serological molecular markers and histoclinical parameters were compared using the standard Chi-2 test.
Nectin-4 was not detected in normal breast epithelium. By contrast, Nectin-4 was expressed in 61% of ductal breast carcinoma vs 6% in lobular type. Expression of Nectin-4 strongly correlated with the basal-like markers EGFR, P53, and P-cadherin, and negatively correlated with the luminal-like markers ER, PR and GATA3. All but one ER/PR-negative tumors expressed Nectin-4. The detection of Nectin-4 in serum improves the follow-up of patients with MBC: the association CEA/CA15.3/Nectin-4 allowed to monitor 74% of these patients compared to 67% with the association CEA/CA15.3. Serum Nectin-4 is a marker of disease progression, and levels correlate with the number of metastases (P = 0.038). Serum Nectin-4 is also a marker of therapeutic efficiency and correlates, in 90% of cases, with clinical evolution.
Nectin-4 is a new tumor-associated antigen for breast carcinoma. Nectin-4 is a new bio-marker whose use could help refine breast cancer taxonomy and improve patients' follow-up. Nectin-4 emerges as a potential target for breast cancer immunotherapy.</description><identifier>ISSN: 1471-2407</identifier><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/1471-2407-7-73</identifier><identifier>PMID: 17474988</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Biological markers ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - blood ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - metabolism ; Cancer ; Cell Adhesion Molecules - biosynthesis ; Cell Adhesion Molecules - blood ; Cell Line, Tumor ; Cells, Cultured ; Cellular Biology ; Diagnosis ; Female ; Gene Expression Regulation, Neoplastic - physiology ; Humans ; Identification and classification ; Life Sciences ; Risk factors</subject><ispartof>BMC cancer, 2007-05, Vol.7 (1), p.73-73, Article 73</ispartof><rights>COPYRIGHT 2007 BioMed Central Ltd.</rights><rights>Attribution</rights><rights>Copyright © 2007 Fabre-Lafay et al; licensee BioMed Central Ltd. 2007 Fabre-Lafay et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b744t-bf1ab18951158c83ce252147a503dc6b6163d8a83ee5180fcd2e4e589084d7a53</citedby><cites>FETCH-LOGICAL-b744t-bf1ab18951158c83ce252147a503dc6b6163d8a83ee5180fcd2e4e589084d7a53</cites><orcidid>0000-0002-2674-3123 ; 0000-0002-7477-3837 ; 0000-0003-1155-1150 ; 0000-0001-7570-7439 ; 0000-0001-8226-3127 ; 0000-0002-6573-633X ; 0000-0002-0286-1299</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868744/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868744/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17474988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01431961$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fabre-Lafay, Stéphanie</creatorcontrib><creatorcontrib>Monville, Florence</creatorcontrib><creatorcontrib>Garrido-Urbani, Sarah</creatorcontrib><creatorcontrib>Berruyer-Pouyet, Carole</creatorcontrib><creatorcontrib>Ginestier, Christophe</creatorcontrib><creatorcontrib>Reymond, Nicolas</creatorcontrib><creatorcontrib>Finetti, Pascal</creatorcontrib><creatorcontrib>Sauvan, Richard</creatorcontrib><creatorcontrib>Adélaïde, José</creatorcontrib><creatorcontrib>Geneix, Jeannine</creatorcontrib><creatorcontrib>Lecocq, Eric</creatorcontrib><creatorcontrib>Popovici, Cornel</creatorcontrib><creatorcontrib>Dubreuil, Patrice</creatorcontrib><creatorcontrib>Viens, Patrice</creatorcontrib><creatorcontrib>Gonçalves, Anthony</creatorcontrib><creatorcontrib>Charafe-Jauffret, Emmanuelle</creatorcontrib><creatorcontrib>Jacquemier, Jocelyne</creatorcontrib><creatorcontrib>Birnbaum, Daniel</creatorcontrib><creatorcontrib>Lopez, Marc</creatorcontrib><title>Nectin-4 is a new histological and serological tumor associated marker for breast cancer</title><title>BMC cancer</title><addtitle>BMC Cancer</addtitle><description>Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importance of large-scale molecular expression analyses to improve taxonomy of breast cancer and prognostic classification. Identification of new molecular markers that refine this taxonomy and improve patient management is a priority in the field of breast cancer research.Nectins are cell adhesion molecules involved in the regulation of epithelial physiology. We present here Nectin-4/PVRL4 as a new histological and serological tumor associated marker for breast carcinoma.
Expression of Nectin-4 protein was measured on a panel of 78 primary cells and cell lines from different origins and 57 breast tumors by FACS analysis and immunohistochemistry (IHC), respectively. mRNA expression was measured by quantitative PCR. Serum Nectin-4 was detected by ELISA and compared with CEA and CA15.3 markers, on panels of 45 sera from healthy donors, 53 sera from patients with non-metastatic breast carcinoma (MBC) at diagnosis, and 182 sera from patients with MBC. Distribution of histological/serological molecular markers and histoclinical parameters were compared using the standard Chi-2 test.
Nectin-4 was not detected in normal breast epithelium. By contrast, Nectin-4 was expressed in 61% of ductal breast carcinoma vs 6% in lobular type. Expression of Nectin-4 strongly correlated with the basal-like markers EGFR, P53, and P-cadherin, and negatively correlated with the luminal-like markers ER, PR and GATA3. All but one ER/PR-negative tumors expressed Nectin-4. The detection of Nectin-4 in serum improves the follow-up of patients with MBC: the association CEA/CA15.3/Nectin-4 allowed to monitor 74% of these patients compared to 67% with the association CEA/CA15.3. Serum Nectin-4 is a marker of disease progression, and levels correlate with the number of metastases (P = 0.038). Serum Nectin-4 is also a marker of therapeutic efficiency and correlates, in 90% of cases, with clinical evolution.
Nectin-4 is a new tumor-associated antigen for breast carcinoma. Nectin-4 is a new bio-marker whose use could help refine breast cancer taxonomy and improve patients' follow-up. Nectin-4 emerges as a potential target for breast cancer immunotherapy.</description><subject>Biological markers</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer</subject><subject>Cell Adhesion Molecules - biosynthesis</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Cell Line, Tumor</subject><subject>Cells, Cultured</subject><subject>Cellular Biology</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Life Sciences</subject><subject>Risk factors</subject><issn>1471-2407</issn><issn>1471-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kk1v1DAQhiMEoqVw5YgiIVXqIcWO7cS5IK0qoJVWIPEhcbMm9mTXJYmL7RT493i7q2UDRXOI_fqZN-MZZ9lzSs4pldUrymtalJzURQr2IDveCw8P1kfZkxCuCaG1JPJxdkRrXvNGyuPs63vU0Y4Fz23IIR_xR762IbrerayGPofR5AH9fh-nwfkcQnDaQkSTD-C_oc-7pLYeIcRcw6jRP80eddAHfLb7nmRf3r75fHFZLD-8u7pYLIu25jwWbUehpbIRlAqpJdNYijLVDYIwo6u2ohUzEiRDFFSSTpsSOQrZEMlNothJdrX1NQ6u1Y23qaBfyoFVd4LzKwU-Wt2jEl2LULWSVA3lRjQtEZ0UrCwFk8KIKnm93nrdTO2ARuMYPfQz0_nJaNdq5W5VmoRM10kGZ1uD9V9pl4ul2miEckabit7SxC62bGvdf342P9FuUJuJqs1EVQqWPE53BXv3fcIQ1WCDxr6HEd0UVE1SX-kd-HILriA1wo6dS5Z6A6tF6jAnpBF1os7voVIYHKx2I3Y26bOEs1lCYiL-jCuYQlBXnz7O2dMDdo3Qx3Vw_RStG8O9VWjvQvDY7XtCido8-n-78OJwbH_w3StnvwEE-_jX</recordid><startdate>20070502</startdate><enddate>20070502</enddate><creator>Fabre-Lafay, Stéphanie</creator><creator>Monville, Florence</creator><creator>Garrido-Urbani, Sarah</creator><creator>Berruyer-Pouyet, Carole</creator><creator>Ginestier, Christophe</creator><creator>Reymond, Nicolas</creator><creator>Finetti, Pascal</creator><creator>Sauvan, Richard</creator><creator>Adélaïde, José</creator><creator>Geneix, Jeannine</creator><creator>Lecocq, Eric</creator><creator>Popovici, Cornel</creator><creator>Dubreuil, Patrice</creator><creator>Viens, Patrice</creator><creator>Gonçalves, Anthony</creator><creator>Charafe-Jauffret, Emmanuelle</creator><creator>Jacquemier, Jocelyne</creator><creator>Birnbaum, Daniel</creator><creator>Lopez, Marc</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2674-3123</orcidid><orcidid>https://orcid.org/0000-0002-7477-3837</orcidid><orcidid>https://orcid.org/0000-0003-1155-1150</orcidid><orcidid>https://orcid.org/0000-0001-7570-7439</orcidid><orcidid>https://orcid.org/0000-0001-8226-3127</orcidid><orcidid>https://orcid.org/0000-0002-6573-633X</orcidid><orcidid>https://orcid.org/0000-0002-0286-1299</orcidid></search><sort><creationdate>20070502</creationdate><title>Nectin-4 is a new histological and serological tumor associated marker for breast cancer</title><author>Fabre-Lafay, Stéphanie ; Monville, Florence ; Garrido-Urbani, Sarah ; Berruyer-Pouyet, Carole ; Ginestier, Christophe ; Reymond, Nicolas ; Finetti, Pascal ; Sauvan, Richard ; Adélaïde, José ; Geneix, Jeannine ; Lecocq, Eric ; Popovici, Cornel ; Dubreuil, Patrice ; Viens, Patrice ; Gonçalves, Anthony ; Charafe-Jauffret, Emmanuelle ; Jacquemier, Jocelyne ; Birnbaum, Daniel ; Lopez, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b744t-bf1ab18951158c83ce252147a503dc6b6163d8a83ee5180fcd2e4e589084d7a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological markers</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cancer</topic><topic>Cell Adhesion Molecules - biosynthesis</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Cell Line, Tumor</topic><topic>Cells, Cultured</topic><topic>Cellular Biology</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Life Sciences</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fabre-Lafay, Stéphanie</creatorcontrib><creatorcontrib>Monville, Florence</creatorcontrib><creatorcontrib>Garrido-Urbani, Sarah</creatorcontrib><creatorcontrib>Berruyer-Pouyet, Carole</creatorcontrib><creatorcontrib>Ginestier, Christophe</creatorcontrib><creatorcontrib>Reymond, Nicolas</creatorcontrib><creatorcontrib>Finetti, Pascal</creatorcontrib><creatorcontrib>Sauvan, Richard</creatorcontrib><creatorcontrib>Adélaïde, José</creatorcontrib><creatorcontrib>Geneix, Jeannine</creatorcontrib><creatorcontrib>Lecocq, Eric</creatorcontrib><creatorcontrib>Popovici, Cornel</creatorcontrib><creatorcontrib>Dubreuil, Patrice</creatorcontrib><creatorcontrib>Viens, Patrice</creatorcontrib><creatorcontrib>Gonçalves, Anthony</creatorcontrib><creatorcontrib>Charafe-Jauffret, Emmanuelle</creatorcontrib><creatorcontrib>Jacquemier, Jocelyne</creatorcontrib><creatorcontrib>Birnbaum, Daniel</creatorcontrib><creatorcontrib>Lopez, Marc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>BMC cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fabre-Lafay, Stéphanie</au><au>Monville, Florence</au><au>Garrido-Urbani, Sarah</au><au>Berruyer-Pouyet, Carole</au><au>Ginestier, Christophe</au><au>Reymond, Nicolas</au><au>Finetti, Pascal</au><au>Sauvan, Richard</au><au>Adélaïde, José</au><au>Geneix, Jeannine</au><au>Lecocq, Eric</au><au>Popovici, Cornel</au><au>Dubreuil, Patrice</au><au>Viens, Patrice</au><au>Gonçalves, Anthony</au><au>Charafe-Jauffret, Emmanuelle</au><au>Jacquemier, Jocelyne</au><au>Birnbaum, Daniel</au><au>Lopez, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nectin-4 is a new histological and serological tumor associated marker for breast cancer</atitle><jtitle>BMC cancer</jtitle><addtitle>BMC Cancer</addtitle><date>2007-05-02</date><risdate>2007</risdate><volume>7</volume><issue>1</issue><spage>73</spage><epage>73</epage><pages>73-73</pages><artnum>73</artnum><issn>1471-2407</issn><eissn>1471-2407</eissn><abstract>Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importance of large-scale molecular expression analyses to improve taxonomy of breast cancer and prognostic classification. Identification of new molecular markers that refine this taxonomy and improve patient management is a priority in the field of breast cancer research.Nectins are cell adhesion molecules involved in the regulation of epithelial physiology. We present here Nectin-4/PVRL4 as a new histological and serological tumor associated marker for breast carcinoma.
Expression of Nectin-4 protein was measured on a panel of 78 primary cells and cell lines from different origins and 57 breast tumors by FACS analysis and immunohistochemistry (IHC), respectively. mRNA expression was measured by quantitative PCR. Serum Nectin-4 was detected by ELISA and compared with CEA and CA15.3 markers, on panels of 45 sera from healthy donors, 53 sera from patients with non-metastatic breast carcinoma (MBC) at diagnosis, and 182 sera from patients with MBC. Distribution of histological/serological molecular markers and histoclinical parameters were compared using the standard Chi-2 test.
Nectin-4 was not detected in normal breast epithelium. By contrast, Nectin-4 was expressed in 61% of ductal breast carcinoma vs 6% in lobular type. Expression of Nectin-4 strongly correlated with the basal-like markers EGFR, P53, and P-cadherin, and negatively correlated with the luminal-like markers ER, PR and GATA3. All but one ER/PR-negative tumors expressed Nectin-4. The detection of Nectin-4 in serum improves the follow-up of patients with MBC: the association CEA/CA15.3/Nectin-4 allowed to monitor 74% of these patients compared to 67% with the association CEA/CA15.3. Serum Nectin-4 is a marker of disease progression, and levels correlate with the number of metastases (P = 0.038). Serum Nectin-4 is also a marker of therapeutic efficiency and correlates, in 90% of cases, with clinical evolution.
Nectin-4 is a new tumor-associated antigen for breast carcinoma. Nectin-4 is a new bio-marker whose use could help refine breast cancer taxonomy and improve patients' follow-up. Nectin-4 emerges as a potential target for breast cancer immunotherapy.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>17474988</pmid><doi>10.1186/1471-2407-7-73</doi><orcidid>https://orcid.org/0000-0002-2674-3123</orcidid><orcidid>https://orcid.org/0000-0002-7477-3837</orcidid><orcidid>https://orcid.org/0000-0003-1155-1150</orcidid><orcidid>https://orcid.org/0000-0001-7570-7439</orcidid><orcidid>https://orcid.org/0000-0001-8226-3127</orcidid><orcidid>https://orcid.org/0000-0002-6573-633X</orcidid><orcidid>https://orcid.org/0000-0002-0286-1299</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biological markers Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - blood Breast cancer Breast Neoplasms - blood Breast Neoplasms - metabolism Cancer Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - blood Cell Line, Tumor Cells, Cultured Cellular Biology Diagnosis Female Gene Expression Regulation, Neoplastic - physiology Humans Identification and classification Life Sciences Risk factors |
title | Nectin-4 is a new histological and serological tumor associated marker for breast cancer |
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