The role of the immune system in posttraumatic stress disorder

Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to traumatic stress. In addition to well-defined psychological and behavioral symptoms, some individuals with PTSD also exhibit elevated concentrations of inflammatory markers, including C-reactive protein, interl...

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Bibliographic Details
Published in:Translational psychiatry 2022-08, Vol.12 (1), p.313-313, Article 313
Main Authors: Katrinli, Seyma, Oliveira, Nayara C. S., Felger, Jennifer C., Michopoulos, Vasiliki, Smith, Alicia K.
Format: Article
Language:English
Subjects:
692/53/2423
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Anxiety
Behavioral Sciences
Biological Psychology
Cytokines
Immune system
Inflammation
Longitudinal studies
Medicine
Medicine & Public Health
Mental disorders
Metabolism
Nervous system
Neurosciences
Pharmacotherapy
Post traumatic stress disorder
Psychiatry
Review
Review Article
Trauma
Tumor necrosis factor-TNF
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Summary:Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to traumatic stress. In addition to well-defined psychological and behavioral symptoms, some individuals with PTSD also exhibit elevated concentrations of inflammatory markers, including C-reactive protein, interleukin-6, and tumor necrosis factor-α. Moreover, PTSD is often co-morbid with immune-related conditions, such as cardiometabolic and autoimmune disorders. Numerous factors, including lifetime trauma burden, biological sex, genetic background, metabolic conditions, and gut microbiota, may contribute to inflammation in PTSD. Importantly, inflammation can influence neural circuits and neurotransmitter signaling in regions of the brain relevant to fear, anxiety, and emotion regulation. Given the link between PTSD and the immune system, current studies are underway to evaluate the efficacy of anti-inflammatory treatments in those with PTSD. Understanding the complex interactions between PTSD and the immune system is essential for future discovery of diagnostic and therapeutic tools.
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-022-02094-7