Can antimicrobial blue light contribute to resistance development? Genome-wide analysis revealed aBL-protective genes in Escherichia coli

Increasing antibiotic resistance and the lack of new antibiotic-like compounds to combat bacterial resistance are significant problems of modern medicine. The development of new alternative therapeutic strategies is extremely important. Antimicrobial blue light (aBL) is an innovative approach to com...

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Bibliographic Details
Published in:Microbiology spectrum 2024-01, Vol.12 (1), p.e0249023-e0249023
Main Authors: Kruszewska-Naczk, Beata, Grinholc, Mariusz, Waleron, Krzysztof, Bandow, Julia Elisabeth, Rapacka-Zdończyk, Aleksandra
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
antimicrobial blue light
Blue Light
Drug Resistance, Microbial
Escherichia coli
Escherichia coli - genetics
Genetics and Molecular Biology
genome-wide analysis
hypersensitive mutants
Microbial Sensitivity Tests
Research Article
resistance
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Summary:Increasing antibiotic resistance and the lack of new antibiotic-like compounds to combat bacterial resistance are significant problems of modern medicine. The development of new alternative therapeutic strategies is extremely important. Antimicrobial blue light (aBL) is an innovative approach to combat multidrug-resistant microorganisms. aBL has a multitarget mode of action; however, the full mechanism of aBL antibacterial action requires further investigation. In addition, the potential risk of resistance development to this treatment should be considered.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02490-23