Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

Two new benzoic acids, cladoslide A ( ) and cladoslide B ( ); one new β-carboline derivative, cladospomine ( ); and one new pyridin-2(1 )-one, cladoslide C ( ), were isolated from the fermentation cultures of the mangrove-derived fungus sp. HNWSW-1, along with the previously reported -acetyl-β-oxotr...

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Bibliographic Details
Published in:Frontiers in chemistry 2021-12, Vol.9, p.773703-773703
Main Authors: Cao, Xi, Guo, Lei, Cai, Caihong, Kong, Fandong, Yuan, Jingzhe, Gai, Cuijuan, Dai, Haofu, Wang, Pei, Mei, Wenli
Format: Article
Language:English
Subjects:
Chemistry
Cladosporium sp
cytotoxicity
mangrove-derived fungus
metabolites
α-glycosidase inhibitor
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Summary:Two new benzoic acids, cladoslide A ( ) and cladoslide B ( ); one new β-carboline derivative, cladospomine ( ); and one new pyridin-2(1 )-one, cladoslide C ( ), were isolated from the fermentation cultures of the mangrove-derived fungus sp. HNWSW-1, along with the previously reported -acetyl-β-oxotryptamine ( ), (4 ,5 ,11 )- -cladospolide B ( ), (4 ,5 ,11 )- -cladospolide B ( ), and (4 ,5 ,11 )- -cladospolide B ( ). Their structures were elucidated by spectroscopic analysis, Rh (OCOCF ) -induced ECD experiments, and Marfey's method. Compound showed cytotoxicity against the K562 cell line with IC values of 13.10 ± 0.08  M. Moreover, compounds and exhibited inhibitory activity against α-glycosidase with IC values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.773703