A Rare Occurrence of Three Primary Malignancies of the Rectum, Breast, and Kidney in the Same Patient: A Case Report and Review of the Literature

An increasing number of patients with multiple primary cancers are encountered due to improved cancer detection, widespread cancer screening, and better cancer treatment. Here, we report such a patient without a family history of malignancies or a known genetic predisposition developing three primar...

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Bibliographic Details
Published in:Case reports in surgery 2019-09, Vol.2019 (2019), p.1-4
Main Authors: Samarasekera, Dharmabandhu Nandadeva, Jayasinghe, Jayan, Wijerathne, Pradeep, Basnayake, Oshan, Jayarajah, Umesh, Seneviratne, Sanjeewa
Format: Article
Language:English
Subjects:
Antigens
Biopsy
Breast
Breast cancer
Cancer
Cancer patients
Cancer screening
Cancer therapies
Carcinoembryonic antigen
Care and treatment
Case Report
Case reports
CEA (Oncology)
Chemotherapy
Colon
Colorectal cancer
Decision making
Diagnosis
Family medical history
Genetics
Health risk assessment
Histology
Invasiveness
Kidney cancer
Kidneys
Literature reviews
Lymph nodes
Lymphatic system
Mammography
Nephrectomy
Oncology
Patients
Rectum
Renal cell carcinoma
Surgeons
Surgery
Tumors
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Summary:An increasing number of patients with multiple primary cancers are encountered due to improved cancer detection, widespread cancer screening, and better cancer treatment. Here, we report such a patient without a family history of malignancies or a known genetic predisposition developing three primary malignancies of the rectum, breast, and kidney. A 63-year-old female who underwent an anterior resection for rectal cancer was detected to have an elevated carcinoembryonic antigen (CEA) level during a routine follow-up, 8 years after the initial surgery. Clinical examination revealed a left breast lump which was confirmed as invasive ductal carcinoma (pT3 pN0 cM0). Imaging and colonoscopy excluded a local recurrence. However, a right renal lesion suggestive of a renal cell carcinoma was detected (pT1a). She underwent left mastectomy with a sentinel lymph node biopsy and a right partial nephrectomy with a curative intent. Postoperatively, CEA levels declined to normal limits. Management of multiple primary malignancies poses a major challenge. A multidisciplinary approach and tailored decision-making for the individual patient help with the optimum outcome.
ISSN:2090-6900
2090-6919
DOI:10.1155/2019/1716029