13-year mortality trends among hospitalized patients with inflammatory bowel disease

• Published in: BMC gastroenterology 2012-06, Vol.12 (1), p.79-79, Article 79
• Main Authors: Sewell, Justin L, Yee, Jr, Hal F
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Colitis, Ulcerative - mortality; Comorbidity; Crohn Disease - mortality; Crohn’s disease; Data Collection; Epidemiology; Female; Gastroenterology; Health aspects; Heart attacks; Hospital Mortality - trends; Hospital patients; Hospitalization; Hospitals; Humans; In-hospital mortality; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - mortality; Logistic Models; Male; Middle Aged; Mortality; Outcomes; Patient outcomes; Ulcerative colitis; United States
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/1471-230X-12-79

Studies document increasing rates of hospitalization among patients with inflammatory bowel disease, but temporal trends for in-hospital mortality among patients with inflammatory bowel disease are not characterized. We sought to determine whether in-hospital mortality changed over a 13-year period among nationwide hospitalizations associated with inflammatory bowel disease. We additionally sought to identify factors correlated with mortality. We used the National Hospital Discharge Survey, a large nationally representative database, for the years 1994 through 2006. Age- and mortality-adjusted rates of in-hospital mortality and standardized mortality ratios were calculated for four time periods. Logistic regression analysis was used to assess associations between advancing time and mortality in adjusted analyses. 150 (0.9%) of 17,393 hospitalizations for patients with inflammatory bowel disease ended in death. Age-adjusted in-hospital mortality decreased from 3.6 deaths per 1,000 hospital days in 1994-96 to 2.4 per 1,000 in 2003-06; standardized mortality ratio decreased from 0.33 to 0.27. Similar trends were seen for patients with ulcerative colitis, but mortality did not change over time among patients with Crohn's disease. Multivariable logistic regression analysis confirmed the significance of these changes in mortality, with 17% decreased odds of in-hospital death per three-year period (P=0.012). Subject age (OR 1.06 per year, P