The effects of BMMSC treatment on lung tissue degeneration in elderly macaques

Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, cancer, among others). So, it is particularly important to find new anti-aging treatments. We...

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Bibliographic Details
Published in:Stem cell research & therapy 2021-03, Vol.12 (1), p.156-156, Article 156
Main Authors: Yang, Yu-Kun, Li, Ye, Wang, Yan-Ying, Ruan, Guang-Ping, Tian, Chuan, Wang, Qiang, He, Huan-Yu, Zhu, Gao-Hong, Fang, Dong, Wang, Mao, Zhu, Xiang-Qing, Pan, Xing-Hua
Format: Article
Language:English
Subjects:
Aging
Airway management
Alveoli
Animals
Antibodies
Apoptosis
BMMSCs
Bone marrow
Capillaries
Cell cycle
Cell proliferation
Chronic obstructive pulmonary disease
Cytokines
Degeneration
Epithelial cells
Epithelium
Ethylenediaminetetraacetic acid
Fibrosis
Geriatrics
Hospitals
Hydrogen peroxide
Idiopathic Pulmonary Fibrosis - genetics
Idiopathic Pulmonary Fibrosis - therapy
Inflammation
Injuries
Intravenous administration
Lung
Lung cancer
Lung degeneration
Lung diseases
Lung diseases, Obstructive
Lymphocytes T
Macaca
Macaque
Mesenchymal Stem Cells
Morphology
Pulmonary Alveoli
Pulmonary fibrosis
Respiratory agents
Risk factors
Senescence
Stem cells
Tumor necrosis factor-TNF
Type II alveolar epithelial cells
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Summary:Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, cancer, among others). So, it is particularly important to find new anti-aging treatments. We systematically screened and evaluated elderly senile multiple organ dysfunction macaque models to determine whether BMMSCs inhibited lung tissue degeneration. The average alveolar area, mean linear intercept (MLI), and fibrosis area in the elderly macaque models were significantly larger than in young rhesus monkeys (p 
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02201-3