Acute oxygen desaturation characterizes pulmonary aspiration in patients with gastroesophageal reflux disease and laryngopharyngeal reflux

The aim of this study was to characterise pulmonary aspiration of refluxate in patients with gastroesophageal reflux disease (GORD) and laryngopharyngeal reflux (LPR) by continuous pulse oximetry (SpO2) during the supine phase of a scintigraphic reflux study. Variables assessed for significance incl...

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Bibliographic Details
Published in:Physiological reports 2022-06, Vol.10 (12), p.e15367-n/a
Main Authors: Weerasinghe, Daminda P., Burton, Leticia, Chicco, Peter, Pearson, Mark, Mackey, Douglas J., Falk, Gregory L.
Format: Article
Language:English
Subjects:
Age
Computed tomography
Esophagus
Gastroesophageal reflux
gastro‐esophageal reflux disease
Gender
Hernia
Hernias
Hypoxia
Intensive care
laryngopharyngeal reflux
Lungs
Original
Oxygen
Oxygen saturation
Patients
Pharynx
Physiology
Pulmonary aspiration
Pulse oximetry
Questionnaires
Scintigraphy
Tomography
Trends
Variables
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Summary:The aim of this study was to characterise pulmonary aspiration of refluxate in patients with gastroesophageal reflux disease (GORD) and laryngopharyngeal reflux (LPR) by continuous pulse oximetry (SpO2) during the supine phase of a scintigraphic reflux study. Variables assessed for significance included age, hiatus hernia, frequency, amplitude of reflux and clearance of reflux from the oesophagus/pharynx. The patients included in this study had established GORD and LPR by clinical history. All patients underwent fused three‐ dimensional scintigraphic/ X‐ray computed tomography (CT) and simultaneous continuous pulse oximetry when supine for 30 minutes. A total of 265 patients (40.4% M, 59.6% F) were studied. Mean age of aspirators was 57.0 years and non‐aspirators was 53.5 years. Seven patients had baseline oxygen saturation
ISSN:2051-817X
DOI:10.14814/phy2.15367