Fish oil rich in eicosapentaenoic acid and docosahexaenoic acid in sow diets modifies oxylipins and immune indicators in colostrum and milk

Colostrum and milk are the first nutrient sources for newborn piglets. In addition, n-3 fatty acids (FAs) and their oxygenated derivatives (oxylipins) have the capacity to modulate immune components. The aim of the current study was to include a fish oil rich in eicosapentaenoic acid (EPA) and docos...

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Published in:Animal (Cambridge, England) England), 2021-12, Vol.15 (12), p.100403-100403, Article 100403
Main Authors: Llauradó-Calero, E., Badiola, I., Delpino-Rius, A., Lizardo, R., Torrallardona, D., Esteve-Garcia, E., Tous, N.
Format: Article
Language:English
Subjects:
Animal Feed - analysis
Animals
Colostrum
Diet - veterinary
Dietary Supplements
Docosahexaenoic Acids
Eicosapentaenoic Acid
Female
Fish Oils
Gas Chromatography-Mass Spectrometry - veterinary
Lactation
Maternal passive immunity
Milk
N-3 long-chain fatty acids
Oxygenated lipid mediators
Oxylipins
Pregnancy
Swine
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Summary:Colostrum and milk are the first nutrient sources for newborn piglets. In addition, n-3 fatty acids (FAs) and their oxygenated derivatives (oxylipins) have the capacity to modulate immune components. The aim of the current study was to include a fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in sow diets to promote an increase of anti-inflammatory molecules in colostrum and milk to benefit piglets. Thirty-six sows were randomly assigned from insemination to the end of lactation to either a control diet with animal fat (15 g/kg in gestation and 30 g/kg in lactation) or an n-3 diet in which animal fat was totally (gestation) or half (lactation) replaced by an equivalent amount of solid fish oil. Performance of sows and piglets was monitored during the study. Colostrum and milk samples were obtained after the birth of the first piglet and at weaning, respectively. From all samples (n = 18 per treatment), FAs were quantified by gas chromatography and immunoglobulins and cytokines by ELISA. Three samples per treatment were randomly selected to analyse oxylipin composition by liquid chromatography-tandem mass spectrometry. In colostrum and in milk, the n-3 FA (P = 0.020 and P 
ISSN:1751-7311
1751-732X
DOI:10.1016/j.animal.2021.100403