DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients

• Published in: Tumor biology 2017-06, Vol.39 (6), p.1010428317714625-1010428317714625
• Main Authors: Han, Binbin, Wang, Jiwen, Gao, Jia, Feng, Shana, Zhu, Yu, Li, Xuexiang, Xiao, Ting, Qi, Jun, Cui, Wei
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antigens; Authorship; Benign; Binding sites; Biomarkers; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Carcinogenesis - genetics; Diagnosis; DNA microarrays; Early Detection of Cancer; Enzymes; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lung cancer; Lung diseases; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lymph nodes; Lymph Nodes - pathology; Male; Medical diagnosis; Medical screening; Metastases; Metastasis; Middle Aged; Neoplasm Metastasis; PARK7 protein; Patients; Protein Deglycase DJ-1 - biosynthesis; Protein Deglycase DJ-1 - genetics; Proteins; Squamous cell carcinoma; Surgery; Thoracic surgery; Tumorigenesis; Tumors
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1177/1010428317714625

DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the activated ras gene. DJ-1 appears to have its greatest effect on tumourigenesis, and it may have a greater impact on early-stage lung cancers. In this study, we proposed to investigate the clinical value of DJ-1 protein in the early diagnosis of lung cancer and compared its diagnostic value with other biomarkers. Preoperative serum DJ-1 levels were measured in 300 lung cancer patients and compared with benign pulmonary disease (n = 44) and healthy volunteers (n = 64). Using tissue microarrays and immunohistochemical analyses, we compared the DJ-1 expression between the primary squamous cell carcinoma tumours and matched metastatic tissues from a lymph node. The baseline preoperative serum DJ-1 of lung cancer patients was significantly higher than that of benign diseases and healthy controls (p