Rac GTPases in Hematological Malignancies

Emerging evidence suggests that crosstalk between hematologic tumor cells and the tumor microenvironment contributes to leukemia and lymphoma cell migration, survival, and proliferation. The supportive tumor cell-microenvironment interactions and the resulting cellular processes require adaptations...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-12, Vol.19 (12), p.4041
Main Authors: Durand-Onaylı, Valerie, Haslauer, Theresa, Härzschel, Andrea, Hartmann, Tanja Nicole
Format: Article
Language:English
Subjects:
Adaptation
cancer
Cell adhesion & migration
Chemokine receptors
Crosstalk
Cytoskeleton
Deregulation
Fibroblasts
Gene expression
Guanosine triphosphatases
Hematology
Integrins
Kinases
Leukemia
Localization
Lymphoma
microenvironment
migration
Morphology
proliferation
Proteins
Rac GTPases
Receptor mechanisms
Review
Roles
Signal transduction
survival
Tumor cells
Tumor microenvironment
Tumors
Tyrosine
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Summary:Emerging evidence suggests that crosstalk between hematologic tumor cells and the tumor microenvironment contributes to leukemia and lymphoma cell migration, survival, and proliferation. The supportive tumor cell-microenvironment interactions and the resulting cellular processes require adaptations and modulations of the cytoskeleton. The Rac subfamily of the Rho family GTPases includes key regulators of the cytoskeleton, with essential functions in both normal and transformed leukocytes. Rac proteins function downstream of receptor tyrosine kinases, chemokine receptors, and integrins, orchestrating a multitude of signals arising from the microenvironment. As such, it is not surprising that deregulation of Rac expression and activation plays a role in the development and progression of hematological malignancies. In this review, we will give an overview of the specific contribution of the deregulation of Rac GTPases in hematologic malignancies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19124041