The Extracellular Matrix and Vesicles Modulate the Breast Tumor Microenvironment

Emerging evidence has shown multiple roles of the tumor microenvironment (TME) components, specifically the extracellular matrix (ECM), in breast cancer development, progression, and metastasis. Aside from the biophysical properties and biochemical composition of the breast ECM, the signaling molecu...

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Bibliographic Details
Published in:Bioengineering (Basel) 2020-10, Vol.7 (4), p.124
Main Authors: Yang, Jun, Bahcecioglu, Gokhan, Zorlutuna, Pinar
Format: Article
Language:English
Subjects:
Bioengineering
Breast cancer
Cell growth
Collagen
Cytokines
Extracellular matrix
Extracellular vesicles
Fibroblasts
Growth factors
Homeostasis
Kinases
Matrix vesicles
Medical research
Metastases
Metastasis
Proteins
Review
Signaling
Tumor microenvironment
Tumor necrosis factor-TNF
Tumors
Vesicles
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Summary:Emerging evidence has shown multiple roles of the tumor microenvironment (TME) components, specifically the extracellular matrix (ECM), in breast cancer development, progression, and metastasis. Aside from the biophysical properties and biochemical composition of the breast ECM, the signaling molecules are extremely important in maintaining homeostasis, and in the breast TME, they serve as the key components that facilitate tumor progression and immune evasion. Extracellular vesicles (EVs), the mediators that convey messages between the cells and their microenvironment through signaling molecules, have just started to capture attention in breast cancer research. In this comprehensive review, we first provide an overview of the impact of ECM in breast cancer progression as well as the alterations occurring in the TME during this process. The critical importance of EVs and their biomolecular contents in breast cancer progression and metastasis are also discussed. Finally, we discuss the potential biomedical or clinical applications of these extracellular components, as well as how they impact treatment outcomes.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering7040124