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The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors
Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, e...
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| Published in: | Diagnostic pathology 2024-08, Vol.19 (1), p.118-9, Article 118 |
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| creator | Šafanda, Adam Kendall Bártů, Michaela Michálková, Romana Švajdler, Marián Shatokhina, Tetiana Laco, Jan Matěj, Radoslav Méhes, Gábor Drozenová, Jana Hausnerová, Jitka Špůrková, Zuzana Škarda, Jozef Hácová, Mária Náležinská, Monika Dundr, Pavel Němejcová, Kristýna |
| description | Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, evaluating its potential utility in differential diagnosis, prognosis, and therapeutic application.
We examined 390 cases of ovarian sex cord-stromal tumors including 281 adult granulosa cell tumors (AGCT), 5 juvenile granulosa cell tumors (JGCT), 33 Sertoli-Leydig cell tumors (SLCT), 50 fibromas/thecomas (F/T), 11 Leydig cell tumors/steroid cell tumors (LCT/SterCT), 5 sex-cord stromal tumors NOS (SCST-NOS), 3 Sertoli cell tumors (SCT), and 2 sclerosing stromal tumors (ScST). Immunohistochemical analysis was performed using TMAs.
Strong expression (> 50%) was observed in all cases of AGCT, JGCT, SLCT, SCST-NOS, SCT and 1 ScST. The other case of ScST exhibited mild expression (5-10%). The negative cases included exclusively F/T and LCT/SterCT, with F/T showing 24% of negative cases and LCT/SterCT comprising 64% of negative cases.
The results of our study indicate that stathmin is neither a prognostic marker nor suitable for the differential diagnosis of challenging cases of ovarian sex cord-stromal tumors. However, its predictive value may be theoretically significant, as a decrease in stathmin expression potentialy influences response to chemotherapy treatment. |
| doi_str_mv | 10.1186/s13000-024-01541-x |
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We examined 390 cases of ovarian sex cord-stromal tumors including 281 adult granulosa cell tumors (AGCT), 5 juvenile granulosa cell tumors (JGCT), 33 Sertoli-Leydig cell tumors (SLCT), 50 fibromas/thecomas (F/T), 11 Leydig cell tumors/steroid cell tumors (LCT/SterCT), 5 sex-cord stromal tumors NOS (SCST-NOS), 3 Sertoli cell tumors (SCT), and 2 sclerosing stromal tumors (ScST). Immunohistochemical analysis was performed using TMAs.
Strong expression (> 50%) was observed in all cases of AGCT, JGCT, SLCT, SCST-NOS, SCT and 1 ScST. The other case of ScST exhibited mild expression (5-10%). The negative cases included exclusively F/T and LCT/SterCT, with F/T showing 24% of negative cases and LCT/SterCT comprising 64% of negative cases.
The results of our study indicate that stathmin is neither a prognostic marker nor suitable for the differential diagnosis of challenging cases of ovarian sex cord-stromal tumors. However, its predictive value may be theoretically significant, as a decrease in stathmin expression potentialy influences response to chemotherapy treatment.</description><identifier>ISSN: 1746-1596</identifier><identifier>EISSN: 1746-1596</identifier><identifier>DOI: 10.1186/s13000-024-01541-x</identifier><identifier>PMID: 39215355</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Analysis ; Biomarkers, Tumor - analysis ; Cancer ; Chemotherapy ; Diagnosis ; Diagnosis, Differential ; Differential diagnosis ; Female ; Health aspects ; Humans ; Immunohistochemistry ; Malignancy ; Medical prognosis ; Middle Aged ; Mitosis ; Mutation ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - therapy ; Ovarian tumors ; Ovaries ; Ovary ; Prognosis ; Sex ; Sex Cord-Gonadal Stromal Tumors - diagnosis ; Sex Cord-Gonadal Stromal Tumors - metabolism ; Sex Cord-Gonadal Stromal Tumors - pathology ; Sex Cord-Gonadal Stromal Tumors - therapy ; Sex cord-stromal tumors ; Stathmin ; Stathmin - analysis ; Stathmin - metabolism ; Tumors ; Variables</subject><ispartof>Diagnostic pathology, 2024-08, Vol.19 (1), p.118-9, Article 118</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c389t-e961361cb5769761ea823f2024ee13661f6a99b2908be4950fe7380e05d0ec823</cites><orcidid>0000-0001-9340-9320</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3102505001?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39215355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šafanda, Adam</creatorcontrib><creatorcontrib>Kendall Bártů, Michaela</creatorcontrib><creatorcontrib>Michálková, Romana</creatorcontrib><creatorcontrib>Švajdler, Marián</creatorcontrib><creatorcontrib>Shatokhina, Tetiana</creatorcontrib><creatorcontrib>Laco, Jan</creatorcontrib><creatorcontrib>Matěj, Radoslav</creatorcontrib><creatorcontrib>Méhes, Gábor</creatorcontrib><creatorcontrib>Drozenová, Jana</creatorcontrib><creatorcontrib>Hausnerová, Jitka</creatorcontrib><creatorcontrib>Špůrková, Zuzana</creatorcontrib><creatorcontrib>Škarda, Jozef</creatorcontrib><creatorcontrib>Hácová, Mária</creatorcontrib><creatorcontrib>Náležinská, Monika</creatorcontrib><creatorcontrib>Dundr, Pavel</creatorcontrib><creatorcontrib>Němejcová, Kristýna</creatorcontrib><title>The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors</title><title>Diagnostic pathology</title><addtitle>Diagn Pathol</addtitle><description>Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, evaluating its potential utility in differential diagnosis, prognosis, and therapeutic application.
We examined 390 cases of ovarian sex cord-stromal tumors including 281 adult granulosa cell tumors (AGCT), 5 juvenile granulosa cell tumors (JGCT), 33 Sertoli-Leydig cell tumors (SLCT), 50 fibromas/thecomas (F/T), 11 Leydig cell tumors/steroid cell tumors (LCT/SterCT), 5 sex-cord stromal tumors NOS (SCST-NOS), 3 Sertoli cell tumors (SCT), and 2 sclerosing stromal tumors (ScST). Immunohistochemical analysis was performed using TMAs.
Strong expression (> 50%) was observed in all cases of AGCT, JGCT, SLCT, SCST-NOS, SCT and 1 ScST. The other case of ScST exhibited mild expression (5-10%). The negative cases included exclusively F/T and LCT/SterCT, with F/T showing 24% of negative cases and LCT/SterCT comprising 64% of negative cases.
The results of our study indicate that stathmin is neither a prognostic marker nor suitable for the differential diagnosis of challenging cases of ovarian sex cord-stromal tumors. 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Academic</collection><collection>Directory of Open Access Journals</collection><jtitle>Diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šafanda, Adam</au><au>Kendall Bártů, Michaela</au><au>Michálková, Romana</au><au>Švajdler, Marián</au><au>Shatokhina, Tetiana</au><au>Laco, Jan</au><au>Matěj, Radoslav</au><au>Méhes, Gábor</au><au>Drozenová, Jana</au><au>Hausnerová, Jitka</au><au>Špůrková, Zuzana</au><au>Škarda, Jozef</au><au>Hácová, Mária</au><au>Náležinská, Monika</au><au>Dundr, Pavel</au><au>Němejcová, Kristýna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors</atitle><jtitle>Diagnostic pathology</jtitle><addtitle>Diagn Pathol</addtitle><date>2024-08-30</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>118</spage><epage>9</epage><pages>118-9</pages><artnum>118</artnum><issn>1746-1596</issn><eissn>1746-1596</eissn><abstract>Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, evaluating its potential utility in differential diagnosis, prognosis, and therapeutic application.
We examined 390 cases of ovarian sex cord-stromal tumors including 281 adult granulosa cell tumors (AGCT), 5 juvenile granulosa cell tumors (JGCT), 33 Sertoli-Leydig cell tumors (SLCT), 50 fibromas/thecomas (F/T), 11 Leydig cell tumors/steroid cell tumors (LCT/SterCT), 5 sex-cord stromal tumors NOS (SCST-NOS), 3 Sertoli cell tumors (SCT), and 2 sclerosing stromal tumors (ScST). Immunohistochemical analysis was performed using TMAs.
Strong expression (> 50%) was observed in all cases of AGCT, JGCT, SLCT, SCST-NOS, SCT and 1 ScST. The other case of ScST exhibited mild expression (5-10%). The negative cases included exclusively F/T and LCT/SterCT, with F/T showing 24% of negative cases and LCT/SterCT comprising 64% of negative cases.
The results of our study indicate that stathmin is neither a prognostic marker nor suitable for the differential diagnosis of challenging cases of ovarian sex cord-stromal tumors. However, its predictive value may be theoretically significant, as a decrease in stathmin expression potentialy influences response to chemotherapy treatment.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39215355</pmid><doi>10.1186/s13000-024-01541-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9340-9320</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Biomarkers, Tumor - analysis Cancer Chemotherapy Diagnosis Diagnosis, Differential Differential diagnosis Female Health aspects Humans Immunohistochemistry Malignancy Medical prognosis Middle Aged Mitosis Mutation Ovarian Neoplasms - diagnosis Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Ovarian tumors Ovaries Ovary Prognosis Sex Sex Cord-Gonadal Stromal Tumors - diagnosis Sex Cord-Gonadal Stromal Tumors - metabolism Sex Cord-Gonadal Stromal Tumors - pathology Sex Cord-Gonadal Stromal Tumors - therapy Sex cord-stromal tumors Stathmin Stathmin - analysis Stathmin - metabolism Tumors Variables |
| title | The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors |
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