Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes

• Published in: Heliyon 2021-08, Vol.7 (8), p.e07693-e07693, Article e07693
• Main Authors: Adeyemi, Jerry O., Saibu, Gbemisola M., Olasunkanmi, Lukman O., Fadaka, Adewale O., Meyer, Mervin, Sibuyi, Nicole R.S., Onwudiwe, Damian C., Oyedeji, Adebola O.
• Format: Article
• Language: English
• Subjects: Anti-inflammatory; Antioxidant; Computational study; Cytotoxicity; Dithiocarbamate; Organotin
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2021.e07693

Methyltin(IV) of butyltin(IV)–N-hydroxyethyl dithiocarbamate complexes, represented as [(CH3)2Sn(L(OH))2] and [(C4H9)2Sn(L(OH))2] respectively were synthesized and characterized using spectroscopic techniques (1H, 13C and 119Sn NMR) and elemental analysis. Both infrared and NMR data showed that, the complexes were formed via two sulphur atoms of the dithiocarbamate group. This mode of coordination was further supported by the DFT calculation, which suggested the formation of a distorted octahedral geometry around the tin atom. The complexes were screened for their antioxidant, cytotoxicity and anti-inflammatory properties. Four different assays including DPPH, nitric oxide, reducing power and hydrogen peroxides were used for the antioxidant studies, while an in vitro anti-inflammatory study was done using albumin denaturation assay. The complexes showed good antioxidant activity, especially in the DPPH assay. Butyltin(IV)–N-hydroxyethyl dithiocarbamate showed better cytotoxicity activity compared to methyltin(IV)–N-hydroxyethyl dithiocarbamate in the selected cell lines, which included KMST-6, Caco-2 and A549 cell lines. The anti-inflammatory activities revealed that the two complexes have useful activities better than diclofenac used as control drug. Organotin; dithiocarbamate; computational study; antioxidant; anti-inflammatory; cytotoxicity.