Immunosuppressants: implications in Orthodontics

INTRODUCTION: There are medications capable of affecting bone metabolism and the rate of tooth movement. Among these medications are the immunosuppressants, which act by repressing the action of T lymphocytes, however they can cause bone loss and consequently lead to osteoporosis. Osteoporosis is a...

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Bibliographic Details
Published in:Dental press journal of orthodontics 2012-04, Vol.17 (2), p.55-61
Main Authors: Santos, Rogério Lacerda dos, Lacerda, Maria Cláudia Mesquita, Gonçalves, Renato Torres, Martins, Marco Aurélio, Souza, Margareth Maria Gomes de
Format: Article
Language:English
Subjects:
Bone
DENTISTRY, ORAL SURGERY & MEDICINE
Immunosuppressant
Tooth movement
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Summary:INTRODUCTION: There are medications capable of affecting bone metabolism and the rate of tooth movement. Among these medications are the immunosuppressants, which act by repressing the action of T lymphocytes, however they can cause bone loss and consequently lead to osteoporosis. Osteoporosis is a common complication following kidney, heart, liver or lung transplantation. The immunosuppressant treatment for preventing organ rejection after transplantation, in general, includes glucocorticoids, cyclosporine, tacrolimus, and sirolimus. All these drugs can have jeopardizing effects on bone mineral homeostasis and consequently influence tooth movement. In recent years, however, the increasing use of immunosuppressants has raised questions about their effects on bone metabolism in patients undergoing orthodontic treatment. OBJECTIVE: The objective of this review study was to inform orthodontists about the influence of immunosuppressants on bone metabolism and tooth movement.
ISSN:2176-9451
2177-6709
2176-9451
2177-6709
DOI:10.1590/S2176-94512012000200012