Angiogenesis and schistosomal granuloma formation

An increasing amount of evidences points to angiogenesis as playing a paramount role in fibrosis development. However granulomas in general, and periovular schistosomal granulomas in particular, are considered avascular structures, although they usually result in dense areas of focal fibrosis. In or...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2005-04, Vol.100 (2), p.183-185
Main Authors: Baptista, Ana Paula, Andrade, Zilton A
Format: Article
Language:English
Subjects:
angiogenesis
Animals
Disease Models, Animal
Female
Fibrosis - parasitology
Fibrosis - pathology
Granuloma - parasitology
Granuloma - pathology
Liver Diseases, Parasitic - pathology
Mice
Neovascularization, Pathologic - parasitology
Neovascularization, Pathologic - pathology
PARASITOLOGY
periovular granuloma
Schistosoma mansoni
Schistosomiasis mansoni - pathology
Time Factors
TROPICAL MEDICINE
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Summary:An increasing amount of evidences points to angiogenesis as playing a paramount role in fibrosis development. However granulomas in general, and periovular schistosomal granulomas in particular, are considered avascular structures, although they usually result in dense areas of focal fibrosis. In order to clarify this apparent paradox, the presence of blood vessels was systematically searched in hepatic schistosomal granulomas of mice, during different stages of the infection, and at different stages of granuloma evolution, by means of vascular injections of colored masses, demonstration of laminin in vascular basement membranes and by ultra structural analysis. Vascular proliferation appeared evident at the early stages of granuloma formation, gradually decreasing thereafter, older granulomas becoming almost avascular structures, sometimes delimited at the periphery by a rich vascular network.
ISSN:0074-0276
1678-8060
0074-0276
1678-8060
DOI:10.1590/S0074-02762005000200012