Symptomatic narcolepsy as a presenting feature of neuromyelitis optica

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness. It can be either primary or symptomatic due to other neurologic disorders. Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder in which symptomatic narcolepsy is being described as one of the core clinical...

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Bibliographic Details
Published in:Annals of the Indian Academy of Neurology 2018-04, Vol.21 (2), p.156-158
Main Authors: Kallollimath, Pradeep, Gujjar, Amruth, Patil, Megharanjini
Format: Article
Language:English
Subjects:
Analysis
Aquaporin 4
Aquaporin antibody
Aquaporins
Care and treatment
Case Report
Consent
Demyelination
Diagnosis
Dysphagia
Hypothalamus
Immunoglobulin G
Magnetic resonance imaging
Narcolepsy
Nervous system diseases
Neuromyelitis
Neuromyelitis optica
NMR
Nuclear magnetic resonance
Patients
Sleep
Sleep and wakefulness
Sleep disorders
Spinal cord
Walking
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Description
Summary:Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness. It can be either primary or symptomatic due to other neurologic disorders. Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder in which symptomatic narcolepsy is being described as one of the core clinical features. Here, we report a patient with NMO who presented with narcolepsy. Signal changes on magnetic resonance imaging in hypothalamus and other periventricular regions of high aquaporin-4 expression should prompt considering NMO as diagnosis. Serum anti-aquaporin-4 IgG antibody testing should be done in such cases, and appropriate treatment should be initiated to prevent further neurological worsening and relapses.
ISSN:0972-2327
1998-3549
DOI:10.4103/aian.AIAN_74_18