Febrile Seizures Cause Depression and Anxiogenic Behaviors in Rats

Febrile seizure (FS) is a common type of seizure occurring in human during infancy and childhood. Although an epileptic seizure is associated with psychiatric disorders and comorbid diseases such as depression, anxiety, autism spectrum disorders, sleep disorders, attention deficits, cognitive impair...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-10, Vol.11 (20), p.3228
Main Authors: Yu, Yeon Hee, Kim, Seong-Wook, Im, Hyuna, Song, Yejin, Kim, Seo Jeong, Lee, Yu Ran, Kim, Gun Woo, Hwang, Changmin, Park, Dae-Kyoon, Kim, Duk-Soo
Format: Article
Language:English
Subjects:
Adult
Animal cognition
Animals
Anxiety
Anxiety - complications
Anxiety disorders
Autism
Behavior
Children
Cognitive ability
Complications and side effects
Convulsions & seizures
Depression - complications
Depression, Mental
Emotional disorders
emotional phenotypes
Epilepsy
Febrile convulsions
febrile seizure
Headache
Hippocampus
Hippocampus - pathology
Humans
Humidity
Infant
Laboratory animals
Light
local field potentials
Mental depression
Mental disorders
Mercury
Migraine
Phenotypes
Rats
Risk factors
Rodents
Seizures
Seizures, Febrile - chemically induced
Seizures, Febrile - pathology
Sleep disorders
theta oscillations
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Summary:Febrile seizure (FS) is a common type of seizure occurring in human during infancy and childhood. Although an epileptic seizure is associated with psychiatric disorders and comorbid diseases such as depression, anxiety, autism spectrum disorders, sleep disorders, attention deficits, cognitive impairment, and migraine, the causal relationship between FS and psychiatric disorders is poorly understood. The objective of the current study was to investigate the relationship of FS occurrence in childhood with the pathogenesis of anxiety disorder and depression using an FS rat model. We induced febrile seizures in infantile rats (11 days postnatal) using a mercury vapor lamp. At 3 weeks and 12 weeks after FS induction, we examined behaviors and recorded local field potentials (LFPs) to assess anxiety and depression disorder. Interestingly, after FS induction in infantile rats, anxiogenic behaviors and depression-like phenotypes were found in both adult and juvenile FS rats. The analysis of LFPs revealed that 4-7 Hz hippocampal theta rhythm, a neural oscillatory marker for anxiety disorder, was significantly increased in FS rats compared with their wild-type littermates. Taken together, our findings suggest that FS occurrence in infants is causally related to increased levels of anxiety-related behaviors and depression-like symptoms in juvenile and adult rodents.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11203228