Matrix metalloproteinase‐2, ‐7, and ‐9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases

Background Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, interstitial lung disease that mainly affects West Highland white terriers (WHWTs) and is characterized by excessive deposition of extracellular matrix (ECM) in the lung. Matrix metalloproteinases (MMPs) participate in remodeling o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary internal medicine 2021-01, Vol.35 (1), p.462-471
Main Authors: Määttä, Merita, Laurila, Henna P., Holopainen, Saila, Aaltonen, Kaisa, Lilja‐Maula, Liisa, Viitanen, Sanna, Rajamäki, Minna M.
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Bronchitis
Bronchoalveolar Lavage Fluid
Bronchoscopy
canine
Cross-Sectional Studies
Dog Diseases
Dogs
Extracellular matrix
gelatinases
Gene expression
Histopathology
Idiopathic Pulmonary Fibrosis - veterinary
Lavage
Lung
Lung diseases
matrilysin
Matrix Metalloproteinase 2
Matrix Metalloproteinase 7
Matrix Metalloproteinase 9
Medical prognosis
Physiology
Plasma
Pneumonia
Pulmonary fibrosis
Respiratory diseases
SMALL ANIMAL
Teaching hospitals
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, interstitial lung disease that mainly affects West Highland white terriers (WHWTs) and is characterized by excessive deposition of extracellular matrix (ECM) in the lung. Matrix metalloproteinases (MMPs) participate in remodeling of ECM. Objectives To compare metalloproteinase‐2, ‐7 and ‐9 activities in blood or bronchoalveolar lavage fluid (BALF) samples or both of CIPF WHWTs with healthy WHWTs, healthy dogs of other breeds, and dogs with other lung diseases and determine if these MMPs could be used as diagnostic and prognostic markers for CIPF. Animals Forty‐four CIPF WHWTs, 24 dogs with chronic bronchitis (CB), 17 with eosinophilic bronchopneumopathy (EBP), 10 with bacterial pneumonia, 39 healthy WHWTs, and 35 healthy dogs of other breeds. Methods Cross‐sectional observational study. Pro‐MMP and active MMP activities were analyzed by zymography. Results In serum, significantly higher (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.15970