PTPRH Alleviates Airway Obstruction and Th2 Inflammation in Asthma as a Protective Factor

PTPRH inhibits EGFR activity directly in cancer patients and activated EGFR induces goblet cell hyperplasia and mucus hypersecretion in asthma. However, the function of PTPRH in asthma remains unknown. The purpose of this study was to access the association of PTPRH with asthma and its underlying me...

Full description

Saved in:
Bibliographic Details
Published in:Journal of asthma and allergy 2022-01, Vol.15, p.133-144
Main Authors: Chen, Feng-Jia, Du, Li-Juan, Zeng, Zhimin, Huang, Xin-Yan, Xu, Chang-Yi, Tan, Wei-Ping, Xie, Can-Mao, Liang, Yu-Xia, Guo, Yu-Biao
Format: Article
Language:English
Subjects:
Airway management
Airway obstruction (Medicine)
AKT protein
Antibodies
Asthma
B cells
egfr/erk1/2/akt
Epidermal growth factor receptors
Epithelial cells
Growth factors
Hospitals
human bronchial epithelial cells
Hyperplasia
Inflammation
Interleukin 13
Lymphocytes T
muc5ac
Mucins
Original Research
Overexpression
Phosphatase
Phosphorylation
Proteins
ptprh
Respiratory function
Respiratory tract
Respiratory tract diseases
Signal transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PTPRH inhibits EGFR activity directly in cancer patients and activated EGFR induces goblet cell hyperplasia and mucus hypersecretion in asthma. However, the function of PTPRH in asthma remains unknown. The purpose of this study was to access the association of PTPRH with asthma and its underlying mechanism. We examined the PTPRH level in asthma patients (n = 108) and healthy controls (n = 35), and analyzed the correlations between PTPRH and asthma-related indicators. Human bronchial epithelial cell (HBECs) transfected with PTPRH and asthma mouse model were set up to investigate the function of PTPRH. The expression of PTPRH was significantly increased and correlated with pulmonary function parameters, including airway obstruction, and T-helper2 (Th2) associated markers in asthma patients. PTPRH increased in the house dust mite (HDM)-induced asthmatic mice, while Th2 airway inflammation and Muc5ac suppressed when treated with PTPRH. Accordingly, PTPRH expression was markedly increased in IL-13-stimulated HBECs but PTPRH over-expression suppressed MUC5AC. Moreover, HBECs transfected with over-expressed PTPRH inhibited the phosphorylation of EGFR, ERK1/2 and AKT, while induced against PTPRH in HBECs dephosphorylated of EGFR, ERK1/2 and AKT. PTPRH reduces MUC5AC secretion to alleviate airway obstruction in asthma via potential phosphorylating of EGFR/ERK1/2/AKT signaling pathway, which may provide possible therapeutic implications for asthma.
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S340059