Local and network-level dysregulation of error processing is associated with binge drinking

• Published in: NeuroImage clinical 2021-01, Vol.32, p.102879-102879, Article 102879
• Main Authors: Alderson Myers, Austin B., Arienzo, Donatello, Molnar, Sean M., Marinkovic, Ksenija
• Format: Article
• Language: English
• Subjects: Alcohol Drinking; Binge Drinking; Cognitive control; Error processing; Ethanol; Functional connectivity; Functional magnetic resonance imaging; Go/NoGo; Humans; Inhibition, Psychological; Magnetic Resonance Imaging; Regular; Young Adult
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2021.102879

•Go/NoGo performance does not differ between binge (BDs) and light drinkers.•BDs show greater BOLD activity to inhibition errors primarily in prefrontal areas.•Greater functional connectivity in the frontal cortex correlates with drinking.•Observed increase in error-related activity may serve a compensatory role.•This is consistent with allostatic hyperexcitability reflecting neuroadaptation. Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inability to refrain from excessive alcohol intake. As a facet of cognitive control, error processing allows for flexible modification of behavior to optimize future outcomes. It is highly relevant to addiction research, as a failure to inhibit excessive drinking results in relapses, which is a hallmark of alcohol use disorder. However, research on local and system-level neural underpinnings of inhibition failures as a function of binge drinking is limited. To address these gaps, functional magnetic resonance imaging (fMRI) was used to examine local changes and interregional functional connectivity during response inhibition errors on a Go/NoGo task. Young adult binge drinkers (BDs) performed equally well as light drinkers (LDs), a group of demographically matched individuals who drink regularly but in low-risk patterns. In contrast, BDs exhibited greater fMRI activity to inhibition errors contrasted with correct NoGo trials in the rostral anterior (rACC) and posterior cingulate cortices (PCC), as well as right middle frontal gyrus (R-MFG). Furthermore, BDs showed increased connectivity between the rACC and right lateral prefrontal cortex, in addition to greater connectivity between the R-MFG and the left ventrolateral and superior frontal cortices. Imaging indices were positively correlated only with alcohol-related measures, but not with those related to moods, disposition, or cognitive capacity. Taken together, greater error-related activity and expanded functional connectivity among prefrontal regions may serve a compensatory role to maintain efficiency of inhibitory control. Aligned with prominent models of addiction, these findings accentuate the importance of top-down control in maintaining low-risk drinking levels. They provide insight into potentially early signs of deter