The Role of the Gastrointestinal System in Neuroinvasion by SARS-CoV-2

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the most devastating pandemics in history. SARS-CoV-2 has infected more than 100 million people worldwide, leading to more than 3.5 million deaths. Initially, the clinical symptoms...

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Bibliographic Details
Published in:Frontiers in neuroscience 2021-07, Vol.15, p.694446-694446
Main Authors: Xu, Jiali, Wu, Zifeng, Zhang, Mi, Liu, Shijiang, Zhou, Ling, Yang, Chun, Liu, Cunming
Format: Article
Language:English
Subjects:
Central nervous system
Coronaviruses
COVID-19
gastrointestinal system
Gastrointestinal tract
gut microbiota
gut- brain axis
Invasiveness
Medical treatment
Middle East respiratory syndrome
Mortality
neuroinvasion
Neuroscience
Pandemics
Respiratory system
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the most devastating pandemics in history. SARS-CoV-2 has infected more than 100 million people worldwide, leading to more than 3.5 million deaths. Initially, the clinical symptoms of SARS-CoV-2 infection were thought to be restricted to the respiratory system. However, further studies have revealed that SARS-CoV-2 can also afflict multiple other organs, including the gastrointestinal tract and central nervous system. The number of gastrointestinal and neurological manifestations after SARS-CoV-2 infection has been rapidly increasing. Most importantly, patients infected with SARS-CoV-2 often exhibit comorbid symptoms in the gastrointestinal and neurological systems. This review aims to explore the pathophysiological mechanisms of neuroinvasion by SARS-CoV-2. SARS-CoV-2 may affect the nervous system by invading the gastrointestinal system. We hope that this review can provide novel ideas for the clinical treatment of the neurological symptoms of SARS-CoV-2 infection and references for developing prevention and treatment strategies.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2021.694446