Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases

It is well documented that life expectancy in developed countries at birth is going to surpass the 20 century. However, regrettably, a potential decline in life expectancy has been proposed for these nations in the 21st century due to a rapid upsurge in the prevalence of fatal degenerative diseases...

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Bibliographic Details
Published in:Iranian journal of basic medical sciences 2020-02, Vol.23 (2), p.140-153
Main Authors: Waheed Janabi, Alhamzah Hasan, Kamboh, Asghar Ali, Saeed, Muhammad, Xiaoyu, Lu, BiBi, Jannat, Majeed, Fatima, Naveed, Muhammad, Mughal, Muhammad Jameel, Korejo, Nazar Ali, Kamboh, Rubina, Alagawany, Mahmoud, Lv, Huixia
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
anti-oxidants
cancers geroprotective
cardiovascular diseases diabetes
Diabetes
dietary supplements nutraceuticals
Flavonoids
Life expectancy
Review
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Summary:It is well documented that life expectancy in developed countries at birth is going to surpass the 20 century. However, regrettably, a potential decline in life expectancy has been proposed for these nations in the 21st century due to a rapid upsurge in the prevalence of fatal degenerative diseases like cardiovascular diseases (CVD), cancer and diabetes. Collectively, these three diseases accounted for 65% of all deaths in urbanized societies and were considered as a dynamic issue for shortening the genetically determined lifespan through increased mortalities, morbidities, disabilities, immense sufferings, and premature aging. These fatal degenerative diseases and premature aging are closely associated with oxidative stress produced by the free radicals in the body. In epidemiologic studies, flavonoid-rich foods (FRF) like fruits, vegetables, and beverages have been associated as protective agents against these diseases. These also have been observed for their geroprotective effects and help in preventing premature aging and deterioration of brain function, which is related to Alzheimer's disease and dementia. In this review, we presented a comprehensive overview of the FRF for their potential role against lifespan-shortening complications, i.e., CVD, cancer, and diabetes. We also have drawn the future perspective and dietary guidelines to reduce the fatal disease burden in urban populations.
ISSN:2008-3866
2008-3874
DOI:10.22038/IJBMS.2019.35125.8353