Factors affecting corneal deformation amplitude measured by Corvis ST in eyes with open-angle glaucoma

• Published in: Indian journal of ophthalmology 2024-04, Vol.72 (4), p.533-537
• Main Authors: Pradhan, Zia S, Sreenivasaiah, Shruthi, Deshmukh, Sujit, Mangala, Lavi, Shroff, Sujani, Devi, Sathi, Webers, Carroll Ab, Rao, Harsha L
• Format: Article
• Language: English
• Subjects: Biomechanics; Cornea; corneal biomechanics; corvis st; deformation amplitude; Diagnosis; Eye; Glaucoma; Methods; Open-angle glaucoma; Original; primary open-angle glaucoma; pseudoexfoliation glaucoma; Tonometry
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/IJO.IJO_822_23

To evaluate the factors affecting corneal deformation amplitude (DA) measured using Corvis ST in eyes with open-angle glaucoma. This prospective, longitudinal study included 48 eyes with open-angle glaucoma who required additional intraocular pressure (IOP)-lowering drops. All eyes underwent a complete eye examination at baseline, including a Corvis ST, which was repeated 4-8 weeks after the change in therapy. Factors affecting the corneal biomechanics, namely the DA, were determined using mixed effect models. The mean age of the cohort was 65.0 ± 7.9 years. The mean IOP reduced from 23.4 ± 5.4 mmHg to 17.9 ± 5 mmHg after the change in glaucoma treatment ( P < 0.001). The DA increased from 0.89 ± 0.16 mm to 1.00 ± 0.13 mm after IOP reduction ( P < 0.001). On mixed effect model analysis, IOP (-0.02 ± 0.001, P < 0.001) and corneal pachymetry (-0.0003 ± 0.0001, P = 0.02) affected the change in the DA. IOP and corneal pachymetry affect the DA and must be accounted for when using Corvis ST to evaluate corneal biomechanics in glaucoma.