Beet Stalks and Leaves ( Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF...

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Bibliographic Details
Published in:Nutrients 2018-07, Vol.10 (7), p.872
Main Authors: Lorizola, Isabela M, Furlan, Cibele P B, Portovedo, Mariana, Milanski, Marciane, Botelho, Patrícia B, Bezerra, Rosângela M N, Sumere, Beatriz R, Rostagno, Maurício A, Capitani, Caroline D
Format: Article
Language:English
Subjects:
antioxidant enzymes
Antioxidants
Blood
Cholesterol
Damage prevention
Dehydration
Fasting
Flavonoids
functional foods
Glucose
Glucose metabolism
Glutathione peroxidase
Glutathione reductase
High fat diet
Leaves
Lipid metabolism
Liver
Malondialdehyde
Metabolism
Mice
Peroxidase
phenolic compounds
Polyphenols
Rodents
Superoxide dismutase
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Summary:Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were supplemented with dehydrated beet stalks and leaves (SL) or beet stalk and leaf ethanolic extract (EX). In terms of Vitexin-rhaminoside equivalents (VRE), EX groups received ~5.91 mg of VRE·100 g diet, while the SL groups received ~3.07 mg VRE·100 g diet. After 8 weeks, we evaluated fasting blood glucose; cholesterol, hepatic Malondialdehyde (MDA) levels and hepatic Glutathione (GSH), Glutathione peroxidase (GPx), Glutathione reductase (GR) and Superoxide dismutase (SOD) activity. Dehydrated beet stalks and leaves (HFSL) attenuated the deleterious effects of a HF diet on lipid metabolism, reduced fasting blood glucose levels, ameliorated cholesterol levels and reduced GPx and GR activities ( < 0.05) compared to the HF group. However; the addition of ethanolic extract from beet stalks and leaves was unable ( > 0.05) to prevent the liver damage caused by HF diet in mice. The presence of flavonoids, such as Vitexin derivatives in beet stalks and leaves can help the liver damage induced by HF diet.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10070872