Toward a SERS Diagnostic Tool for Discrimination between Cancerous and Normal Bladder Tissues via Analysis of the Extracellular Fluid

Vibrational spectroscopy provides the possibility for sensitive and precise detection of chemical changes in biomolecules due to development of cancers. In this work, label-free near-infrared surface enhanced Raman spectroscopy (SERS) was applied for the differentiation between cancerous and normal...

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Published in:ACS omega 2022-03, Vol.7 (12), p.10539-10549
Main Authors: Zacharovas, Edvinas, Velička, Martynas, Platkevičius, Gediminas, Čekauskas, Albertas, Želvys, Aru̅nas, Niaura, Gediminas, Šablinskas, Valdas
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container_end_page 10549
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container_title ACS omega
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creator Zacharovas, Edvinas
Velička, Martynas
Platkevičius, Gediminas
Čekauskas, Albertas
Želvys, Aru̅nas
Niaura, Gediminas
Šablinskas, Valdas
description Vibrational spectroscopy provides the possibility for sensitive and precise detection of chemical changes in biomolecules due to development of cancers. In this work, label-free near-infrared surface enhanced Raman spectroscopy (SERS) was applied for the differentiation between cancerous and normal human bladder tissues via analysis of the extracellular fluid of the tissue. Specific cancer-related SERS marker bands were identified by using a 1064 nm excitation wavelength. The prominent spectral marker band was found to be located near 1052 cm–1 and was assigned to the C–C, C–O, and C–N stretching vibrations of lactic acid and/or cysteine molecules. The correct identification of 80% of samples is achieved with even limited data set and could be further improved. The further development of such a detection method could be implemented in clinical practice for the aid of surgeons in determining of boundaries of malignant tumors during the surgery.
doi_str_mv 10.1021/acsomega.2c00058
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title Toward a SERS Diagnostic Tool for Discrimination between Cancerous and Normal Bladder Tissues via Analysis of the Extracellular Fluid
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