Genome and atrial fibrillation

Atrial fibrillation (AF), the most common type of arrhythmia, can cause several adverse effects, such as stroke, heart failure, and cognitive dysfunction, also in addition to reducing quality of life and increasing mortality. Evidence suggests that AF is caused by a combination of genetic and clinic...

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Bibliographic Details
Published in:Journal of arrhythmia 2023-06, Vol.39 (3), p.303-309
Main Author: Nakano, Yukiko
Format: Article
Language:English
Subjects:
Atrial fibrillation
Cardiac arrhythmia
Clinical Review
Clinical Reviews
Consortia
Gene loci
Genes
Genetic research
genome
Genomes
Genomics
GWAS
Health aspects
Heart
Hypertension
MicroRNAs
Mortality
Mutation
Peptides
polygenic risk factor
Potassium
Quality of life
Risk factors
Signal transduction
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Summary:Atrial fibrillation (AF), the most common type of arrhythmia, can cause several adverse effects, such as stroke, heart failure, and cognitive dysfunction, also in addition to reducing quality of life and increasing mortality. Evidence suggests that AF is caused by a combination of genetic and clinical predispositions. In line with this, genetic studies on AF have progressed significantly through linkage studies, genome‐wide association studies, use of polygenic risk scores, and studies on rare coding variations, gradually elucidating the relationship between genes and the pathogenesis and prognosis of AF. This article will review current trends in genetic analysis concerning AF.
ISSN:1880-4276
1883-2148
DOI:10.1002/joa3.12847