Specialized Metabolites of the Lichen Vulpicida pinastri Act as Photoprotective Agents

The extreme resiliency of lichens to UV radiations makes them an interesting model to find new photoprotective agents acting as UV-blockers and antioxidant. In this research, using a new in vitro method designed to overcome the shortage of material associated to many studies dealing with natural pro...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-07, Vol.22 (7), p.1162
Main Authors: Legouin, Béatrice, Lohézic-Le Dévéhat, Françoise, Ferron, Solenn, Rouaud, Isabelle, Le Pogam, Pierre, Cornevin, Laurence, Bertrand, Michel, Boustie, Joël
Format: Article
Language:English
Subjects:
Acids
antioxidant
Antioxidants
Antioxidants - isolation & purification
Antioxidants - pharmacology
Benzofurans - isolation & purification
Benzofurans - pharmacology
Cell lines
Chemical Sciences
Circular dichroism
Cytotoxicity
Dichroism
Furans - isolation & purification
Furans - pharmacology
Humans
In vitro methods and tests
Keratinocytes - cytology
Keratinocytes - drug effects
lichen
Lichens
Lichens - chemistry
Metabolites
Natural products
Phenylacetates - isolation & purification
Phenylacetates - pharmacology
photoprotection
phototoxicity
Plant Extracts - chemistry
pulvinic acid
Radiation-Protective Agents - isolation & purification
Radiation-Protective Agents - pharmacology
Reagents
Superoxide
synergy
Ultraviolet Rays
Usnic acid
Vulpicida
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Summary:The extreme resiliency of lichens to UV radiations makes them an interesting model to find new photoprotective agents acting as UV-blockers and antioxidant. In this research, using a new in vitro method designed to overcome the shortage of material associated to many studies dealing with natural products, we show that the three major compounds isolated from the lichen , vulpinic acid, pinastric acid and usnic acid, were UV blocker agents. Antioxidant assays evidenced superoxide anion scavenging activity. Combination of the most promising compounds against UVB and UVB radiations, usnic acid, vulpinic acid and pinastric acid, increased the photoprotective activity. At the same time, they were found not cytotoxic on keratinocyte cell lines and photostable in the UVA and UVB ranges. Thus, lichens represent an attractive source to find good candidate ingredients as photoprotective agents. Additionally, the uncommon scalemic usnic acid mixture in this species was proven through electronic circular dichroism calculation.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22071162