The Effects of Selenium on Bone Health: From Element to Therapeutics

Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversia...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (2), p.392
Main Authors: Yang, Taeyoung, Lee, So-Young, Park, Kyung-Chae, Park, Sin-Hyung, Chung, Jaiwoo, Lee, Soonchul
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Biosynthesis
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone diseases
Bone mass
bone mineral density
Climate change
Computer architecture
Dietary Supplements
Disease
Fractures
Hormones
Humans
Metabolism
Metabolites
Nanoparticles
Nanoparticles - chemistry
Natural products
Osteoporosis
Osteoporosis - drug therapy
Osteoporosis - metabolism
Proteins
Review
Selenium
Selenium - chemistry
Selenium - pharmacology
Selenium - therapeutic use
selenoprotein
Selenoproteins - metabolism
Sulfur
therapeutics
Thyroid gland
Toxicity
Trace elements
Trace Elements - metabolism
Trace Elements - pharmacology
Trace Elements - therapeutic use
Transfer RNA
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Summary:Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27020392