Optimal obesity- and lipid-related indices for predicting type 2 diabetes in middle-aged and elderly Chinese

• Published in: Scientific reports 2024-05, Vol.14 (1), p.10901-10901, Article 10901
• Main Authors: Zhang, Xiaoyun, Wang, Ying, Li, Yuqing, Gui, Jiaofeng, Mei, Yujin, Yang, Xue, Liu, Haiyang, Guo, Lei-lei, Li, Jinlong, Lei, Yunxiao, Li, Xiaoping, Sun, Lu, Yang, Liu, Yuan, Ting, Wang, Congzhi, Zhang, Dongmei, Li, Jing, Liu, Mingming, Hua, Ying, Zhang, Lin
• Format: Article
• Language: English
• Subjects: 692/163/2743/137; 692/163/2743/2099; 692/163/2743/393; 692/499; 692/53/2423; 692/699/2743/137; 692/699/2743/393; Adipose tissue; Aged; Anthropometric indices; Body Mass Index; Body measurements; China - epidemiology; Cross-Sectional Studies; Cross-sectional study; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; East Asian People; Female; Females; Humanities and Social Sciences; Humans; Lipids; Lipids - blood; Longitudinal Studies; Male; Males; Middle age; Middle Aged; Middle-aged and elderly Chinese; multidisciplinary; Obesity; Obesity - blood; Obesity - diagnosis; Regression analysis; Risk Factors; ROC Curve; Science; Science (multidisciplinary); Type 2 diabetes; Waist Circumference
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-61592-4

To investigate the screening and predicting functions of obesity- and lipid-related indices for type 2 diabetes (T2D) in middle-aged and elderly Chinese, as well as the ideal predicted cut-off value. This study's data comes from the 2011 China Health and Retirement Longitudinal Study (CHARLS). A cross-sectional study design was used to investigate the relationship of T2D and 13 obesity- and lipid-related indices, including body mass index (BMI), waist circumference (WC), waist–height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), triglyceride- glucose index (TyG index) and its correlation index (TyG-BMI, TyG-WC, TyG-WHtR). The unadjusted and adjusted correlations between 13 indices and T2D were assessed using binary logistic regression analysis. The receiver operating characteristic curve (ROC) was used to determine the usefulness of anthropometric indices for screening for T2D and determining their cut‑off value, sensitivity, specificity, and area under the curve (AUC). The study comprised 9488 people aged 45 years or above in total, of whom 4354 (45.89%) were males and 5134 (54.11%) were females. Among them were 716 male cases of T2D (16.44%) and 870 female cases of T2D (16.95%). A total of 13 obesity- and lipid-related indices were independently associated with T2D risk after adjusted for confounding factors ( P