Immobilizing type I collagen via natural cross-linker genipin to enhance the osteogenic responses to titanium implant surface

Titanium (Ti) surface, with an essentially bioinert character, is not easy to actively initiate interactions with surrounding biological tissue. In this study, we developed a novel surface modification to enhance the osteogenic response to Ti surface in orthopedic and dental implant applications. Th...

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Bibliographic Details
Published in:Journal of materials research and technology 2021-11, Vol.15, p.885-900
Main Authors: Liu, Chia-Fei, Chang, Kai-Chun, Sun, Ying-Sui, Nguyen, Diem Thuy, Huang, Her-Hsiung
Format: Article
Language:English
Subjects:
Genipin
Natural cross-linker
Osteogenic response
Surface modification
Titanium implant
Type I collagen
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Summary:Titanium (Ti) surface, with an essentially bioinert character, is not easy to actively initiate interactions with surrounding biological tissue. In this study, we developed a novel surface modification to enhance the osteogenic response to Ti surface in orthopedic and dental implant applications. The proposed surface modification combined alkaline treatment and type I collagen immobilization through using a natural cross-linker genipin. A variety of experiments were used to characterize the resulting surfaces in terms of morphology, chemistry, roughness, hydrophilicity, and bioactivity. We also assessed the responses of human bone marrow mesenchymal stem cells (hMSCs) to Ti surfaces in terms of adhesion, migration, proliferation, mineralization, and differentiation. Results showed that the modified Ti surfaces revealed a hydrophilic (water and diiodomethane contact angles
ISSN:2238-7854
DOI:10.1016/j.jmrt.2021.08.058