Management of pemphigoid vegetans with mycophenolate mofetil: A case report

Pemphigoid vegetans is a rare variant of bullous pemphigoid. Only 13 cases have been documented in the medical literature. The lesions clinically resemble pemphigus vegetans, but the histology is consistent with bullous pemphigoid. We present the case of a 63-year-old woman with painful vesicular an...

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Published in:SAGE open medical case reports 2024-01, Vol.12, p.2050313X241231535
Main Authors: Mathieu, Audrey, Chababi-Atallah, Myrna, Allard-Chamard, Hugues, Fernandes, Carolina Lucena
Format: Article
Language:English
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JCMS Case Report
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Summary:Pemphigoid vegetans is a rare variant of bullous pemphigoid. Only 13 cases have been documented in the medical literature. The lesions clinically resemble pemphigus vegetans, but the histology is consistent with bullous pemphigoid. We present the case of a 63-year-old woman with painful vesicular and vegetative lesions progressing for 4 months. Histopathology showed a dermal-epidermal cleavage, epidermal acanthosis and an eosinophilic infiltrate. Direct immunofluorescence showed linear deposition of IgG and IgA at the junctional level. The diagnosis of pemphigoid vegetans was retained and successfully treated with oral corticosteroid, dapsone and mycophenolate mofetil.
ISSN:2050-313X
2050-313X
DOI:10.1177/2050313X241231535