The relationship between blood lipids and endometriosis: a cross-sectional study from NHANES (1999-2006) and a bidirectional Mendelian randomization study

Observational studies suggest a link between blood lipid levels and endometriosis risk, but clinical evidence is limited and causality has not been established. This study aims to clarify this relationship using NHANES data (1999-2006) and bidirectional Mendelian Randomization (MR) analysis. We anal...

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Published in:Journal of psychosomatic obstetrics and gynaecology 2024-12, Vol.45 (1), p.2441196
Main Authors: Peng, Dingchuan, Zhong, Wei, Wang, Yiran, Fu, Yiyao, Shang, Wei
Format: Article
Language:English
Subjects:
Adult
Bidirectional Mendelian Randomization study
Blood lipids
Cross-Sectional Studies
Cross-sectional study
Endometriosis
Endometriosis - blood
Endometriosis - epidemiology
Endometriosis - genetics
Female
Genome-Wide Association Study
Humans
Lipids - blood
Mendelian Randomization Analysis
Middle Aged
NHANES
Nutrition Surveys
Risk Factors
Single nucleotide polymorphism
Triglycerides - blood
United States - epidemiology
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Summary:Observational studies suggest a link between blood lipid levels and endometriosis risk, but clinical evidence is limited and causality has not been established. This study aims to clarify this relationship using NHANES data (1999-2006) and bidirectional Mendelian Randomization (MR) analysis. We analyzed NHANES data to explore the relationship between blood lipids and endometriosis risk using multivariable logistic regression, nonlinear testing, and trend analysis. For causal inference, MR was performed using GWAS data from the UK Biobank (lipid levels) and the Finnish Endometriosis Database (endometriosis). In NHANES (n=2,201), elevated triglycerides (TG) were significantly associated with increased endometriosis risk (OR, 2.10; 95% CI, 1.00-3.49; p < 0.05). MR analysis confirmed this association (OR, 1.19; 95% CI, 1.07-1.32; p < 0.006) and suggested HDL may protect against endometriosis (OR, 0.79; 95% CI, 0.63-0.99; p < 0.05). Additionally, bidirectional MR indicated that endometriosis may also contribute to TG dysregulation (OR, 1.02; 95% CI, 1.01-1.03; p < 0.006). Our findings suggest that elevated TG levels may increase endometriosis risk, while HDL may provide a protective effect. These results offer new insights and may inform future management strategies for endometriosis. However, large-scale longitudinal studies are needed to further validate these associations.
ISSN:0167-482X
1743-8942
1743-8942
DOI:10.1080/0167482X.2024.2441196