Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: Dataset of 2,891 compounds

• Published in: Data in brief 2020-12, Vol.33, p.106492-106492, Article 106492
• Main Authors: Thieulent, Côme, Fortier, Christine, Munier-Lehmann, Hélène, Suzanne, Peggy, Dallemagne, Patrick, Zientara, Stephan, Hans, Aymeric, Paillot, Romain, Vidalain, Pierre-Olivier, Pronost, Stéphane, Hue, Erika
• Format: Article
• Language: English
• Subjects: Animal biology; Antiviral; Chemical library screening; Data; Equid herpesvirus-1; Life Sciences; Real-time cell assay; Veterinary medicine and animal Health
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2020.106492

Data presented in this article are associated with the research article “Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone and in combination” [1]. These data correspond to the in vitro screening of 2,891 potential antiviral compounds against equid herpesvirus-1 (EHV-1) based on impedance measurements using the xCELLigence® RTCA MP System. This dataset includes compounds from three different libraries: i) 1,199 compounds from the Prestwick® Chemical Library, which contains mostly US Food and Drug Administration approved drugs (Prestwick® Chemical, Illkirch, France); ii) 1,651 compounds from the Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN, Caen, France); iii) 41 compounds (called herein in-house antiviral library) selected for their effects against different human viruses. Compounds effective against EHV-1 were selected using the area under normalised curves (AUCn) and the time required for the Cell Index to decrease by 50% after virus infection (CIT50). The full dataset from the screen is made publicly available for further analyses.