Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study

Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. average length of stay, complications) as well as of secondary nephrotic syndrome (SNS) is...

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Bibliographic Details
Published in:BMC nephrology 2019-02, Vol.20 (1), p.45-10, Article 45
Main Authors: Franke, Ingo, Aydin, Malik, Kurylowicz, Lisa, Lopez, Corinna Elke Llamas, Ganschow, Rainer, Lentze, Michael J, Born, Mark
Format: Article
Language:English
Subjects:
Acute kidney failure
Adolescent
Adrenal Cortex Hormones - therapeutic use
Age Factors
Bacteria
Bacterial infections
Biopsy
Care and treatment
Child
Child, Hospitalized - statistics & numerical data
Child, Preschool
Childhood
Children
Chronic kidney failure
Comorbidity
Complication
Drug Resistance
Epidemiology
ESPED
Ethics
Female
Follow-Up Studies
Germany - epidemiology
Glomerulosclerosis, Focal Segmental - epidemiology
Glomerulosclerosis, Focal Segmental - therapy
Health Surveys
Hospitals
Humans
Hypertension
Hypertension - epidemiology
Independent sample
Infant
Infant, Newborn
Infections - epidemiology
Kidney diseases
Kidney failure
Length of Stay - statistics & numerical data
Male
Medical prognosis
Nephrology
Nephrotic syndrome
Nephrotic Syndrome - epidemiology
Nephrotic Syndrome - therapy
Patient outcomes
Patients
Pediatric diseases
Pediatric research
Pediatrics
Primary nephrotic syndrome
Purpura
Questionnaires
Renal failure
Schonlein-Henoch purpura
Secondary nephrotic syndrome
Studies
Turkey - ethnology
Urinary tract
Urinary tract infections
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Summary:Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. average length of stay, complications) as well as of secondary nephrotic syndrome (SNS) is not well known. A nationwide ESPED follow-up study presenting the clinical course and management of children with NS in Germany. In course of 2 years, 347 children developed the first onset of NS, hereof 326 patients (93.9%) had a primary NS, and 19 patients had a SNS (missing data in 2 cases), the majority due to a Henoch-Schönlein Purpura. Patients with steroid-resistant NS (SRNS) stayed significantly longer in hospital than children with steroid-sensitive NS (25.2 vs. 13.3 d, p 
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-019-1233-1