Association between Self-Reported Gluten Avoidance and Irritable Bowel Syndrome: Findings of the NutriNet-Santé Study

• Published in: Nutrients 2021-11, Vol.13 (11), p.4147
• Main Authors: Reuzé, Anouk, Delvert, Rosalie, Perrin, Laëtitia, Benamouzig, Robert, Sabaté, Jean-Marc, Bouchoucha, Michel, Allès, Benjamin, Touvier, Mathilde, Hercberg, Serge, Julia, Chantal, Kesse-Guyot, Emmanuelle
• Format: Article
• Language: English
• Subjects: Aged; Avoidance; Barley; Celiac disease; Constipation; Cross-Sectional Studies; Diagnostic Self Evaluation; Diet; Diet Surveys; Diet, Gluten-Free - psychology; Diet, Gluten-Free - statistics & numerical data; dietary exclusion; Dietary restrictions; Female; Food; France - epidemiology; functional gastrointestinal disorder; Gluten; gluten-free diet; Humans; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - diet therapy; Irritable Bowel Syndrome - epidemiology; Irritable Bowel Syndrome - psychology; Lactose; Lifestyles; Male; Middle Aged; Nutrition research; Nutritional status; Patients; Population; Questionnaires; Regression analysis; self-management; Self-Management - psychology; Self-Management - statistics & numerical data; Sociodemographics; Surveys and Questionnaires
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13114147

Self-management of irritable bowel syndrome (IBS) is increasingly focusing on exclusion diets. In particular; patients are showing a significant interest in the gluten-free diet for the treatment of IBS. However; the lack of scientific evidence prevents the establishment of clear dietary guidelines and attention is needed as dietary restriction can lead to potentially adverse effects. This cross-sectional study aims to explore the practice of gluten avoidance in participants identified with IBS in a large cohort of non-celiac French adults. The population included 15,103 participants of the NutriNet-Santé study who completed a functional gastrointestinal disorder questionnaire based on the Rome III criteria to identify IBS in 2013 and a food avoidance questionnaire in 2016. Data on diet and anthropometric and sociodemographic characteristics were collected. Multivariate logistic regression models were used to compare the avoidance of gluten between IBS and non-IBS participants. Participants were mainly women (73.4%) and the mean age in this population was 55.8 ± 13.2 years. Among these individuals, 804 (5.4%) participants were identified as IBS cases. Among them, the prevalence of gluten avoidance was estimated at 14.8%, of which 3.0% reported total avoidance; versus 8.8% and 1.6% in non-IBS participants. After adjustments; gluten avoidance was higher in IBS participants compared to their non-IBS counterparts: (OR = 1.86; 95%CI = 1.21, 2.85) for total and (OR = 1.71; 95%CI = 1.36, 2.14) for partial avoidance. Participants identified with IBS were more associated with gluten avoidance than non-IBS participants. Further studies are needed to explore the long-term consequences of dietary interventions and to provide consistent dietary guidance connected to patient perception.