Palladium on Layered Double Hydroxide: A Heterogeneous System for the Enol Phosphate Carbon-Oxygen Bond Activation in Aqueous Media

In this work, a new catalytic approach for the C-O activation of enol phosphates based on a palladium supported on layered double hydroxide was developed. In this case, two different ketene aminal phosphates were used as models to study the synthesis of α-phenyl enecarbamates N-Boc/CBz under the Suz...

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Bibliographic Details
Published in:Journal of chemistry 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Malta, Luiz Fernando B., Santos, Raquel V., Silva, Aires da Conceição, Senra, Jaqueline D., Simas, Alessandro B. C.
Format: Article
Language:English
Subjects:
Chemical bonds
Chemical research
Hydroxides
Metal catalysts
Palladium
Phosphates
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Summary:In this work, a new catalytic approach for the C-O activation of enol phosphates based on a palladium supported on layered double hydroxide was developed. In this case, two different ketene aminal phosphates were used as models to study the synthesis of α-phenyl enecarbamates N-Boc/CBz under the Suzuki-Miyaura conditions. The use of an ortho-bromoaniline as precursor allowed the synthesis of the 2-phenyl indole through an arylation/Heck cyclization. Catalyst reusability enabled the synthesis of the heterocycle in moderate yields for four consecutive runs.
ISSN:2090-9063
2090-9071
DOI:10.1155/2017/8418939