Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy

Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined d...

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Published in:Journal of community hospital internal medicine perspectives 2017-10, Vol.7 (4), p.265-268
Main Authors: Wazir, Shoaib M, Ghobrial, Ibrahim
Format: Article
Language:English
Subjects:
Anemia
Aplastic anemia
Autoimmunity
Bone marrow
Bone marrow transplantation
Case Report
Case reports
Central nervous system diseases
Copper
Degeneration
Diet
Folic acid
Foregut
Gastrointestinal surgery
Hematology
Intravenous administration
Leukopenia
Lymphoma
Malabsorption
Myelodysplastic syndrome
myelopathy
Neutropenia
Nutrient deficiency
Nutrition
Parenteral nutrition
Peripheral neuropathy
Risk analysis
Risk factors
Spinal cord
Surgery
Thrombocytopenia
Toxicity
Transplantation
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description Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement. Hematological, but not neurological, manifestations respond promptly to copper replacement, making early diagnosis essential for good outcome. Common risk factors for copper deficiency are foregut surgery, dietary deficiency, enteropathies with malabsorption, and prolonged intravenous nutrition (total parenteral nutrition). We present a unique case of copper deficiency, with no apparent known risk factors.
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subjects Anemia
Aplastic anemia
Autoimmunity
Bone marrow
Bone marrow transplantation
Case Report
Case reports
Central nervous system diseases
Copper
Degeneration
Diet
Folic acid
Foregut
Gastrointestinal surgery
Hematology
Intravenous administration
Leukopenia
Lymphoma
Malabsorption
Myelodysplastic syndrome
myelopathy
Neutropenia
Nutrient deficiency
Nutrition
Parenteral nutrition
Peripheral neuropathy
Risk analysis
Risk factors
Spinal cord
Surgery
Thrombocytopenia
Toxicity
Transplantation
title Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy
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